Keystone Innovation Collaborative

10/14/2026

📍 Central PA Entrepreneurs: JOIN US November 5th at Franklin & Marshall College for Merge ! Details & free RSVP⤵
https://www.eventbrite.com/e/merge-lancaster-tickets-1993462887158

09/29/2026

10 Pennsylvania Startups Nurturing America's Health Future ⤵️

's hospitals and research institutions produce world-leading science every year. From stroke-detecting wearables to new nanomedicines, these 10 are turning research innovations into the diagnostics, therapeutics, and the tools clinicians need to catch disease earlier and treat it better.

⚕️ Meet 10 Pennsylvania companies redefining health & life sciences:

Actuated Medical (Bellefonte) Maureen Mulvihill: Medical device developer, including one improving the delivery of brain-directed therapies.

Neuralert Technologies (Philadelphia) Det Ansinn: A wearable stroke-detection device that alerts hospital staff the moment symptoms appear.

Duo Oncology (Pittsburgh) Sam Rothstein: Responsive nanomedicine that replaces toxic chemotherapy agents while maintaining high drug levels inside tumors.

HEARTio (Pittsburgh) Utkars Jain: Digital diagnostics that analyze biosignals from ECGs to predict heart attacks before they happen.

Fourth State Therapeutics (State College) Ali Kazemi: Medical devices employing cold atmospheric plasma systems for burn wound treatment.

Mandeville Therapeutics (Pittsburgh) Isaac Fisher: Therapeutics treating chronic kidney disease.

​​BioLattice (Philadelphia) Amelia Zellander: An engineered synthetic cornea substitute for donated tissues used in cornea transplants.

Scribble (Malvern) Sandeep Banga: AI that listens at the bedside during home health visits and automatically completes medical documentation.

InnSight Technology (Pittsburgh) Leanne Labriola: Handheld diagnostic device that measures biomarkers in tear fluid to guide disease diagnosis.

Thiopoly (Pittsburgh) Douglas Descalzi: Connected medication management for ambulatory clinics and outpatient facilities.

🩺 One state, ten companies building toward the next era of and . Do you know another Pennsylvania-based MedTech or LifeSci company that should be on the list? Tag them here and/or share what you’re building with us at→ https://keystoneinnovate.com/joinus

09/25/2026

Our recent KeystoneMerge founders of who presented at The Candy Factory in June have some very exciting news: they will be appearing on the season premiere of Shark Tank on Wednesday, September 30 @ 9pm on ABC!

Congrats to Andrew, Jeremy and the team - we will definitely be tuning in to watch! 📺

See the Ball 2 “pitch” on the Shark Tank premiere, Sept 30th at 9pm!

09/22/2026

10 Pennsylvania Startups Gearing Up America's Industrial Future ⤵️

Advanced manufacturing in today is being rebuilt from the ground up. From newly developed to critical mineral recovery to mobile 3D concrete printing, these 10 Pennsylvania are proving that the 4th revolution doesn't have to happen somewhere else. Pennsylvania already has the factories, the workforce, and over a century of know-how. These startups and founders are the ones turning that foundation into the smart, automated production of the next industrial era.

⚙️Meet 10 Pennsylvania companies rebuilding advanced manufacturing:

spotLESS Materials (State College) Birgitt Boschitsch: Bio-inspired smooth surface coating that reduces buildup on surfaces.

MXene Inc (Philadelphia) Sebastian Osswald: 2D nanomaterial engineered into powders, inks, and paints for electronic and thermal shielding applications.

Magnitude Instruments (State College) Eric Kennehan: Low noise spectrometers that enable researcher use without an expert level understanding of laser technologies.

Surface Design Solutions (Pittsburgh) Tevis Jacobs: Physics-informed machine learning built to optimize manufacturing surfaces.

SusMaX (Philadelphia) Mo Balapour, Ph.D.: Converting waste coal combustion byproducts into aggregate for the construction industry.

Anactisis (Pittsburgh) Athanasios Karamalidis: Recovering valuable critical minerals from industrial waste streams.

X-Hab 3D (State College) Bruce Kraselsky: Creating structures using mobile robotic 3D concrete printing systems.

Tandem Repeat (Philadelphia) Melik Demirel: Biomanufactured protein fibers produced at scale as an alternative to animal-based fibers.

Bedrock Semiconductor Inc. (Pittsburgh) Troy Baker: GaN-on-GaN semiconductor technology built for next-generation power efficiency.

Workers First (Pittsburgh) Matthew Borowiak: A material that nullifies acid spills on contact to protect industrial workers from injury.

🏗️The next industrial era is being built right here in PA by these 10 startups, and many more. Do you know another Pennsylvania-based company that should be on the list? Tag them here and/or share what you’re building with us at→ www.keystoneinnovate.com/joinus

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09/14/2026

10 Pennsylvania Startups Compiling America's Technological Future ⤵️

and aren't just a Silicon Valley story. is quietly building the autonomous systems that will run warehouses, inspect infrastructure, and support workers in the decades to come. From the factory floor to underwater robots, these 10 startups are showing that Pennsylvania has the engineering depth to lead in robotics and AI.

🦾 Meet 10 Pennsylvania companies pioneering robotics & AI:

Freespace Robotics (Pittsburgh) Robert Szczerba: Full warehouse automation system that stores, retrieves, sorts, buffers, and more.

Aquatonomy (Pittsburgh) Xiaoyu Kaess: Underwater robots used for 3D scans and multi-sensor data in complex or GPS restricted environments.

Serpent Robotics (Philadelphia) Margaret Zhu: A ground controlled robotic branch-cutting system that trims and cuts trees as well as transports debris.

Scout Robotics (Philadelphia) Tejas Agarwal: Predictive maintenance platform for train infrastructure and tracks using LiDAR, thermal imaging, and RGB.

Journey Robotics (Pittsburgh) Reeg Allen: Airport automation systems for baggage handling built to make air travel faster and more seamless.

Estat Actuation (Pittsburgh) Stuart Diller: Electroadhesive clutch technology that is lighter, more compact, and more efficient than conventional clutches.

Glacian Technologies Inc (State College) Wangda Zuo: Physics-based and AI-driven cooling optimization software that frees up data center electrical capacity.

Pixlel (Gettysburg) Jake Grim: AI design agent that builds and publishes professional small business all-in-one websites in seconds with wraparound digital services.

iTruckr (Pittsburgh) Camilo Ramirez: AI-powered trucking management platform that automates dispatch tasks and communication for carriers and dispatchers.

TRAiNED Inc (Pittsburgh) Jonathan Freed: Automates mortgage document workflows and loan processing for lenders.

🔟 Ten companies powering the next era of AI and robotics. Do you know a PA-based robotics or AI that should be on the list?? Tag the founder here or share what you’re building with us at https://keystoneinnovate.com/joinus

09/08/2026

10 Pennsylvania Startups Powering America's Energy Future ⤵️

is one of the states that provides a foundation for America's , as a net producer and exporter today, and in the future as energy technology evolves. From battery chemistry to grid sensing to next-gen fuels, some of the deepest energy R&D happening in the country right now is happening in PA.

⚡️ Meet 10 up-and-coming Pennsylvania startups rewiring the energy industry:

FastLion Energy (State College) Eric Rountree: Next-generation lithium-ion battery technology using advanced intra-cell thermal management.

Clear Solar Corporation (Pittsburgh) Michael Provenzano-Lin: Dust-shield technology adapted to keep solar panels clean without water or manual labor.

Woodland Biomass Innovations (Wellsboro) Luca Pandolfi: Converts woody biomass into sustainable gasoline that works in vehicles and infrastructure.

FlowCellutions (Pittsburgh) Becca Segel: The first state-of-health monitoring system built specifically for flow batteries.

Graphonos Materials (Pittsburgh) Aime Laurent Twizerimana, PhD: Producing graphite from ethane to supply the US battery industry.

SeaLion Energy (Pittsburgh) Reeja Jayan: Nanocomposite coatings that can extend battery life, regenerate spent battery cells, and cut costs.

Metal Light Inc. (Philadelphia) Ryan Goethals: Battery architecture using shelf-stable zinc and aluminum to deliver reliable, dense electrical loads.

Sensible Photonics (Allison Park) Paul Ohodnicki: An optical fiber sensing platform for energy storage and management.

GenHydro Inc (Lancaster) Eric Schraud: Turning waste aluminum into hydrogen and energy.

Super Powers Mobility (New Kensington) Jonathan Powers: 100% electric UTVs that maintain high performance.

🔟 Ten EnergyTech startups. One state. Do you know another PA company that should be on this list?? Tag the founder here or share what you’re building with us at https://keystoneinnovate.com/joinus

09/01/2026

10 Pennsylvania Startups Growing America's Agricultural Future ⤵️

's farmland has always been productive. What's new is how much of today’s innovation happening on PA farms is coming from tech . From drone-based aerial seeding to improved fertilizer technology, these 10 Pennsylvania startups are rebuilding from the soil up, to be more efficient, more sustainable - and they’re grown right here in PA.

🌱 Meet 10 up-and-coming Pennsylvania startup companies:

Phospholutions (State College) Hunter Swisher: Phosphorus fertilizer that improves soil phosphorus efficiency.

(State College) Perry Edwards: A platform for early disease detection and nutrition in .

(Pittsburgh) Grant Wilkinson: Vegetation management technology to deliver herbicide only to invasive plants and targeted areas.

(Carlisle) Molly Cheatum: Drone seed distribution that regenerates soil through precise aerial overseeding with diverse seed mixes.

(Pittsburgh) Dylan Lew: Autonomous bio-digesters converting food waste into liquid fertilizer that earns for you.

(Ambridge) Brian Scott: Peat-free, up-cycled potting mixes made from recycled paper fiber.

(Warminster) Thomas Tillett: AI-driven immune intelligence infrastructure for animal health.

(Columbia) Hema Ravindran: Devices that cleans barn air 24/7 paired with an AI-powered air-quality monitoring system to protect flocks from disease.

(Philadelphia) Daniel Foy: A data analytics platform that collects behavioral data and turns it into AI-driven insights for producers.

Smallhold (West Chester) Tariq Jawad: A large distributed grower for a variety of specialty fresh products as well as consumer packaged goods.

🔟 Ten companies all in one state, figuring out how to grow more of what feeds, protects, and sustains us all.

🧑‍🌾 Do you know another PA company that should be on this list?? Tag the founder here or share what you’re building with us at https://keystoneinnovate.com/joinus

08/25/2026

📣 We are excited to launch a free 5-week Small Business Lab starting next month for and area entrepreneurs with support from M&T Bank! Details and application→ https://keystoneinnovate.com/blog/kic-m-and-t-bank-small-business-mini-lab-2026

💸 The Lab is open to companies with under $1M in annual revenue and that have been in business less than 5 years, and who are based in or serving York or Lancaster county. The Lab begins on Wednesday, September 23rd, and runs 5 consecutive Wednesday evenings until October 21st, with some sessions led by our partners at ASSETS and Finanta, and week 5 culminating with $1000 in pitch competition cash prizes!

✅ Each week, participants will leave with something they can use immediately: a one-page plan built for a lender or landlord, a set of tools for business configured on their own devices, a checklist for protecting what they've already built, and by the final session, a 90-second they have rehearsed and delivered out loud in front of a room. Applications take about 3 minutes and are open now at bit.ly/mini-lab

07/22/2026