05/08/2026
Presenting on "Strengthening TB Prevention" during the 'Reinforcing the Benefits, Eligibility Criteria, and Correct Use of 3HP: South African TB Preventive Treatment Guidelines Overview' webinar, Dr. Lesego Mawela, Clinical Management of Patients on 3HP at National Department of Health (South Africa), explained that 3HP is a combination of high-dose isoniazid and rifapentine taken once a week for 12 weeks (three months).
He also explained that infection is not the same as disease and that 3HP is used to treat latent infection, helping prevent it from progressing to active TB disease in people at higher risk.
"We do not use 3HP for people where we suspect they have active TB or TB disease. We only use it for latent TB."
He said 3HP can be given to all HIV-negative people who are eligible for preventive treatment. For people living with HIV, it can be used by those who are virally suppressed on a dolutegravir (DTG)-based regimen. However, it is not recommended for people who have recently started DTG and are not yet virally suppressed, pregnant women or anyone weighing less than 25 kg.
World Health Organization (WHO)