22/10/2024
🔥 Nếu bạn muốn tìm hiểu về cơ hội thực tập và học Ph.D (được hỗ trợ tài chính hoàn toàn) tại Mechanobiology Institute (MBI), thuộc National University of Singapore (NUS), dưới đây sẽ là một cơ hội hấp dẫn để gặp gỡ và hiểu thêm về viện MBI, và các chương trình nghiên cứu của viện thông qua chuyến thăm của lãnh đạo MBI. Hãy đọc phần tiếng Anh để biết thêm chi tiết các bạn nhé!
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English version:
🔥 We are thrilled to announce that we will organize the seminar given by delegates from the Mechanobiology Institute (MBI), National University of Singapore (NUS)
In this event, you will have opportunities to gain insights about the MBI of NUS’s research, which belongs to top institutions in the world. Remarkably, they also provide information about their fully funded internship and Ph.D program.
⏰ Time: 12:45 – 14:45, Oct 25 2024
Session 1: Research Talk | 12:45 – 13:35
Session 2: MBI Graduate Programme Introduction | 13:45 – 14:45
📌 Location: Music Dance room, Broadway E.
Registration link: https://forms.office.com/r/Gt2hukgghW
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Introduction:
Signal transduction is the primary process by which cells respond to physical and chemical changes. While chemical cues such as hormones, neurotransmitters, and growth factors have been widely studied, physical cues, such as forces and mechanics generated by the extracellular matrix or cell-cell interaction, are also of importance in regulating our systems at different biological levels. Mechanobiology is an emerging field focusing on understanding how individual cells and proteins contribute to the mechanosensing and mechanotransduction of physical forces.
Dr. Toyama, deputy director, and principal investigator at Mechanobiology Institute (MBI), National University of Singapore (NUS), will be discussing his research entitled "The Physics of Cellular Drama: When Mechanics Meets Cell Death" in this upcoming seminar. He will also be providing information about the current undergraduate internships and graduate programs available at MBI.
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The title of the talk is: “The Physics of Cellular Drama: When Mechanics Meets Cell Death”
Every day, over 10 billion cells in our body undergo apoptosis, or programmed cell death. This vital mechanism ensures the elimination of unnecessary or damaged cells. When apoptosis goes wrong, it can lead to serious conditions such as cancer.
Within our tissues, some cells are programmed to die and are pushed out by their neighboring non-dying cells - a process called apoptotic cell extrusion. This extrusion is driven by the formation and contraction of a contractile cable, made of actin and myosin, in both the dying and neighboring cells. This mechanical process changes the tension in nearby cells, creating an unexpected link between cell death and mechanics.
Our research explores this fascinating connection. We've discovered that these mechanical changes due to cell death can be a driving force for tissue movement during embryo development (Toyama et al., Science, 2010) and even determine the fate of neighboring cells (Kawaue et al., Developmental Cell, 2023). These findings required a multidisciplinary approach, combining biology with engineering and physics, as traditional biological approaches alone couldn't have revealed them.
In this presentation, I'll share examples from our research that highlight the power of this multidisciplinary approach. I'll begin by introducing the emerging field of Mechanobiology, which explores 1) how physical factors like forces and mechanics influence biological systems at the molecular, cellular, and tissue levels, and 2) how cells sense these physical factors and convert mechanical stimuli into biochemical signals. I hope this presentation will introduce you to a hidden world where physics and biology intertwine to orchestrate the drama of cellular life and death.
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Short bio of the speaker:
Dr. Toyama pursued his graduate studies in physics and engineering at Osaka University and his undergraduate studies at Hokkaido University in Japan. He earned his Ph.D. in Engineering in 2003, with a focus on plasma physics and laser-driven nuclear fusion. After completing his doctoral work, he shifted his focus to biophysics and mechanobiology during his postdoctoral research at Duke University under the mentorship of Prof. Glenn Edwards and Prof. Dan Kiehart. In 2010, Dr. Toyama joined the Department of Biological Sciences at the National University of Singapore as an Assistant Professor and was later promoted to Associate Professor in 2018. Since 2010, he has been a Principal Investigator at the Mechanobiology Institute, and since 2019, he has served as Deputy Director at the same institute.
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