12/04/2025
Fascinating indeed - show us the science 😎 Peace at Home Project at Waypoint Ranch
Bryan Johnson (the tech guy spending millions to reverse ageing) just did something rather unique.
He took 5.24 grams of psilocybin mushrooms while livestreaming the whole thing, vibing to Grimes and tracking a bunch of biomarkers.
Then he posted the data on X, and honestly, it's fascinating.
The numbers are striking. His inflammation marker (hsCRP) dropped over 35% to basically undetectable levels.
His stress hormones tanked (cortisol down 42%, DHEA-S down 45%) putting him into what he calls "parasympathetic dominance," aka deep relaxation mode.
His estradiol tripled (still normal range), likely because psilocybin triggers neuroprotective pathways.
All of this aligns with actual clinical research on high-dose psilocybin reducing inflammation and stress markers.
he also used a thermal imaging camera to track his temperature across his body.
His core temp rose 1.5-2°F. His chest bloomed with heat. His nose and lips cooled (emotional intensity), cheeks warmed (joy, sadness), forehead cooled (introspection).
At the peak, his heart rate jumped 15 bpm and his oxygen saturation dropped 5% - all signs of his nervous system lighting up.
It's the first visualisation of its kind, showing what a psychedelic experience actually looks like on the body.
But here's what got me. The day after, Johnson called it "one of the best days of my life—healing, energizing and full of love."
People who watched the livestream started calling their parents and friends to express gratitude.
Someone who's built his brand on ruthless optimisation suddenly talking about human connection and hope.
Look, Johnson is a lot.
The longevity obsession can feel dystopian. But watching Silicon Valley's most data-obsessed biohacker find healing through mushrooms and emerge talking about love?
That might be the cultural moment psychedelics needed. More data plus more humanity. Maybe it’s a glimpse at the future of wellness.
