10/12/2026
🧬 New research is helping deepen our understanding of cleft conditions.
For more than 16 years, Operation Smile's International Family Study has brought together families, researchers and health care professionals from around the world to explore one important question: Why do cleft conditions occur?
Because the study includes families from diverse ancestral backgrounds and communities that have historically been underrepresented in genetic research, it helps researchers gain insights that may not be possible through more limited studies alone.
Recent findings are providing important new clues and contributing to a growing understanding of the many factors associated with cleft conditions. These discoveries help advance research and create new opportunities to learn more about how cleft develops.
This work is connected to Operation Smile’s broader effort to expand access to comprehensive cleft care and strengthen local health systems. Research alone cannot close gaps in access to care, but it can inform and improve support for patients, their families and health care teams around the world.
📖 Read more about the latest findings: https://www.operationsmile.org/story/why-research-matters-new-clues-about-cleft-development/