05/27/2026
IDPH would like to alert responders to reports of overdoses related to cychlorphine, a novel synthetic opioid, and “pink co***ne” a mixture of various substances including ketamine,
M**A, co***ne, methamphetamine and opioids Naloxone and opioid reversal agents are still recommended, but additional doses may be required
Background Cychlorphine
Cychlorphine (N-Propionitrile Chlorphine) has been identified in samples from the unregulated
drug supply in Illinois and in postmortem toxicology in at least three substance-related fatalities in Cook County since November 2025. Cychlorphine belongs to an emergent subclass of synthetic opioids referred to as “orphine analogs”. Orphine analogs first emerged in illicit drug markets in 2020 and continues to diversify with at least six different analogs confirmed in recent years.
Cychlorphine is approximately 10x more potent than fentanyl. It has been detected alone and in
mixtures with fentanyl or other substances such as methamphetamine, bromazolam, and/or co***ne.
With cychlorphine’s increased potency and being commonly found in mixtures with other opioids. Be prepared to treat suspected opioid overdoses with additional doses of naloxone.
Pink Cocaine/Tucibi/Tuci/Tusi
IDPH has received reports of overdoses due to a mixture of substances commonly known as
“pink co***ne” (also known as tucibi, tuci, or tusi). Pink co***ne is a powdered mixture of substances
which is dyed pink. It may have a sweet smell and typically produces mind-altering hallucinogenic
effects. The composition of each batch can vary widely and people who consume pink co***ne are
likely unaware of the range of serious effects possible.
Pink co***ne contains a variety of different substances but is often a mixture of ketamine with (M**A), methamphetamine, co***ne, and/or opioids. This unregulated polysubstance mixture often contains ketamine mixed with stimulants and/or depressant and symptoms may vary due to the amount of each substance in the mixture. Adverse effects include hallucinations, anxiety, vomiting
and more. At higher concentrations, adverse effects can include seizures, heart arrhythmia, coma, respiratory depression and death.