Cure Alzheimer's Fund

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Cure Alzheimer's Fund

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Cure Alzheimer's Fund, a non-profit funding research to prevent, slow, or reverse Alzheimer's. 100% of general donations go to our research program.

Since its founding in 2004, Cure Alzheimer’s Fund has provided grants to some of the world’s leading researchers and contributed more than $196 million to research. Its funded initiatives have been responsible for many key breakthroughs in understanding the causes and pathology of Alzheimer’s disease. Cure Alzheimer’s Fund has received a 4-star rating for 13 consecutive years from Charity Navigator. With 100% of general donations supporting our research program, Cure Alzheimer’s Fund has been able to provide grants to many of the best scientific minds in the field of Alzheimer’s research. We do not receive any government funding. The Board of Directors, Trustees, and a core group of donors cover all overhead expenses. We are grateful for all of the donors who have supported our research and to the scientists who are working diligently and passionately to find a cure for Alzheimer's disease.

11/02/2026

November is National Alzheimer's Disease Awareness Month, and we celebrate the memories that shape us and the people who make them matter.

From family to community, our connections and the memories we make together are worth protecting. That's why Cure Alzheimer's Fund supports bold research to prevent, slow, and reverse Alzheimer's disease.

Let's keep our memories, together.

Join us at curealz.org/together

10/30/2026

What if one of the key drivers of Alzheimer’s-related sleep loss lies in the brain’s immune response?

CureAlz-funded researchers at the University of Kentucky found that overactive immune cells in the brain, called microglia, may play a significant role in sleep disruption in Alzheimer’s disease. In a mouse model, temporarily reducing these inflammatory cells restored more than two hours of sleep per day, even though amyloid plaques remained unchanged.

The findings suggest that improving sleep in Alzheimer’s may not depend on removing plaques alone. Targeting brain inflammation could offer a new approach to improving quality of life and potentially addressing the cycle of poor sleep with cognitive decline. While these findings have not yet been demonstrated in humans, the CureAlz-funded study highlights the important connection between inflammation, sleep, and brain health, and could help inform future treatments.

Read the full story: https://ow.ly/UMzb5102wOE

10/28/2026

Go behind the scenes with Meg Smith, Cure Alzheimer’s Fund’s CEO, and Dr. Rudy Tanzi, Chair of the CureAlz Research Leadership Group and Alzheimer’s research leader at Mass General Brigham, as they share the story of how years of bold, collaborative science funded by CureAlz helped pave the way for a pivotal moment in the search for new Alzheimer’s treatments.

More than a decade ago, CureAlz funded the foundational research that led to the development of Alzheimer’s in a Dish, a research model that allows scientists to study key features of the disease in human brain cells grown in the laboratory. This model has since become an invaluable tool for rapidly screening FDA-approved drugs and natural products for their effects on Alzheimer’s pathology and for identifying promising candidates for further investigation.

Now, promising candidates identified through this research are moving toward human clinical trials, with Dr. Tanzi and his collaborators at Mass General Brigham awarded up to $41 million in federal funding from ARPA-H to advance this work.

10/26/2026

Did you know your brain goes through its own wash cycle every night while you sleep?

Throughout the day, your brain generates waste as part of its normal activities. To clear that waste and keep things running smoothly, the brain has its own "washing machine," also known as the glymphatic system.

This cleaning system is particularly active while we sleep, which is one of the many reasons why protecting our rest is important for protecting our brain health.

Curious how it works? Watch the video and learn more at curealz.org/sleep

10/21/2026

More than a decade ago, Cure Alzheimer's Fund invested in bold, early-stage Alzheimer's research that helped lay the groundwork for a significant new federal grant.

Now, with up to $41 million in funding over three years, CureAlz-funded researcher Dr. Rudolph Tanzi and his colleagues at Mass General Brigham and the McCance Center for Brain Health at MGH will test through human clinical trials whether natural products and existing FDA-approved drugs are effective in preventing or slowing Alzheimer's disease progression.

This is just one story of many. Cure Alzheimer's Fund invests early in bold science that is moving us closer to a cure.

Read the full story: curealz.org/news-and-events/from-alzheimers-in-a-dish-to-clinical-trials/

10/19/2026

How exactly does the interaction between amyloid and tau contribute to Alzheimer’s disease?

Amyloid and tau are proteins found naturally in the brain that can build up abnormally in Alzheimer’s, forming amyloid plaques and tau tangles. In prior research, Zhao Sun, PhD, found that preventing amyloid plaques before tau tangles began to form spread slowed disease progression. Targeting amyloid after tau tangles began to spread did not have the same effect.

Now, with funding from Cure Alzheimer’s Fund, Dr. Sun is building on these findings to investigate what happens during this critical window between amyloid buildup and the formation and spread of tau tangles. Understanding this transition could reveal new ways to intervene earlier and identify new therapeutic targets for slowing Alzheimer’s disease.

By funding research that builds on promising discoveries, CureAlz enables scientists like Dr. Sun to pursue critical questions about how Alzheimer’s progresses and uncover new paths toward treatment. Learn more about Dr. Sun’s project and other funded research: https://curealz.org/the-research/

10/15/2026

What began as a small local 5K road race to honor a loved one has become a powerful community running toward a cure for Alzheimer’s disease.

In 2014, Jess and Bob Rice launched Jog Your Memory in honor of Jess’s mother, Carol Caley, who was diagnosed with Alzheimer's disease. Since then, Jog Your Memory has grown into its own nonprofit organization, bringing together more than 1,000 in-person and remote runners for its annual event in Needham, MA, and raising more than $2 million to support Alzheimer’s research and local families.

As longtime CureAlz Heroes, Jess and Bob’s hope for the future is one we all share: “We hope, one day, not to need to have a race, but to gather together instead to celebrate the achievement of finding a cure for this disease. And we have high hopes.” We’re grateful to Jess, Bob, and the entire Jog Your Memory community for their extraordinary dedication to advancing research towards a cure.

Read their inspiring story and learn how you can get involved or become a CureAlz Hero, like Bob and Jess: https://curealz.org/news-and-events/high-hopes-with-jog-your-memory/

10/08/2026

Today is DAF Day! A nationwide celebration of the impact of donor-advised funds (DAFs).

If you have a DAF, this is your chance to join donors across the country in giving together and supporting Cure Alzheimer’s Fund. Every grant recommended through your DAF to support CureAlz advances bold science aimed at preventing, slowing, and curing Alzheimer’s disease.

Learn more and give now: curealz.org/giving/ways-to-donate/

10/05/2026

We are excited to welcome Angela Gomez-Arboledas, PhD, to the CureAlz team as Senior Director, Grant Management.

With extensive experience in the Alzheimer’s disease space, Angela will play a lead role in supporting CureAlz’s grant portfolio and identifying the most promising research ideas for funding. Angela’s prior research encompasses neuroinflammation, glia, and the role of complement in synaptic pruning.

We are delighted to have Angela on board. Welcome, Angela!

Address

Wellesley, MA

Telephone

+17812373800

Website

https://curealz.org/, https://curealz.org/

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