10/16/2026
Why do we need support for basic science? Because successful drugs take decades to develop.
The FDA just approved a new drug for Parkinson’s disease that could help patients control symptoms with a once-daily pill. Tavapadon, sold under the name Juvmo, is expected to become available this month through AbbVie. The drug offers an alternative to levodopa, the gold standard treatment for some of the symptoms of Parkinson’s, and until now the only option for many patients.
The drug grew out of decades of research by Richard B. Mailman, a UVA School of Medicine professor of pharmacology and neuroscience, and Xuemei Huang, chair of UVA Health’s Department of Neurology, much of it published in ASPET’s Journal of Pharmacology and Experimental Therapeutics (https://jpet.aspetjournals.org/action/doSearch?type=quicksearch&text1=mailman&field1=AllField).
According to UVA Health, Dr. Mailman’s breakthrough came in 1984, when he recognized that existing drugs designed to activate dopamine receptors targeted a different group, called D2-like receptors. His experiments suggested that D1-like receptors accounted for most of levodopa’s benefits. He also suspected that targeting them would avoid many side effects associated with existing drugs of this type.
Every drug has a story. Every medication we take to improve our health or our lives is the result of years or decades of work by scientists.
ASPET congratulates Dr. Mailman, Dr. Huang, and all the researchers who contributed to the development of this drug. We hope it leads to a new era in treatment for people with Parkinson’s disease.
🔗News story: https://www.fauquiernow.com/news/fda-approves-parkinsons-drug-based-on-university-of-virginia-research-21d3d710
The FDA has approved Juvmo, a once-daily Parkinson’s pill developed from decades of University of Virginia research, with AbbVie expected to make it available t...