10/14/2026
A small real-world study is adding evidence about a long-acting HIV treatment combination for people with limited options. POZ reports that all 46 participants receiving lenacapavir plus cabotegravir maintained or achieved an undetectable viral load during a median follow-up of nearly two years. The combination is not approved as an HIV treatment, the study had no comparison group and two clinical trials are planned. This early evidence should not be used to change treatment without a qualified HIV clinician.
The new approach replaces rilpivirine with lenacapavir, a long-acting drug that attacks HIV in a different way.