Type 1 Diabetes International Foundation

06/17/2026

https://pubmed.ncbi.nlm.nih.gov/41827917/

These findings showed, in our specific cohort of pediatric patients, the existence of a phenotypic gradient between T1D and monogenic diabetes, with atypical diabetes occupying an intermediate position, including when stratified by DIAMODIA criteria.

06/14/2026

https://pubmed.ncbi.nlm.nih.gov/31291970/

Variants of HNF1B and the K-ATP channel genes were more frequently involved in MgD than previously reported. Phenotype overlapping makes the diagnosis of MgD difficult in adolescents/adults and underlies the benefit of NGS in clinically selected patients.

06/11/2026

https://pubmed.ncbi.nlm.nih.gov/42009259/

Nationwide cohorts from Japan and India show monogenic diabetes is present in a considerable proportion of young, non-obese individuals with diabetes. Clinical presentations are heterogeneous; notably, only up to ∼ 70% of cases had three-generation family history. These findings call for broader g...

05/06/2026

So true...

03/26/2026

https://pmc.ncbi.nlm.nih.gov/articles/PMC1119303/

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03/04/2026

https://pubmed.ncbi.nlm.nih.gov/41625734/

These findings demonstrate a high diagnostic yield (15.3%) for MD and emphasize the need to broaden testing criteria to enable precise, gene-guided and on time treatment decisions.

02/27/2026

https://pubmed.ncbi.nlm.nih.gov/41367630/

This study underscores the clinical and genetic heterogeneity of MODY in the pediatric population and reinforces the value of comprehensive NGS panels for accurate diagnosis, even in patients who do not fully meet classical MODY criteria. The identification of novel GCK variants and the detec...

02/17/2026

https://pubmed.ncbi.nlm.nih.gov/41670436/

Next-generation sequencing (NGS) is increasingly used for diagnosing monogenic forms of diabetes, including Maturity-Onset Diabetes of the Young (MODY). We aimed to evaluate the utility of NGS in patients with clinical suspicion of MODY, analyzing genotype-phenotype correlations. A total of 150 unre...