Project Main St.

Project Main St. Our mission is to help those afflicted with ALS by providing direct financial assistance 🤍 Welcome To Project Main St. No cure has yet been found for ALS.

Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig’s disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. About 10 percent of those individuals with ALS survive for 10 or more years. Our mission is to improve the quality of life for individuals afflicted with Amyotrophic Lateral

Sclerosis (ALS) and their families by lessening the financial burden associated with this devastating disease. HOW TO HELP

Project Main St. is a non-profit, volunteer organization that relies on private donations to enable us to help those in need. We are a 501(c)(3) non-profit organization and all donations are tax-deductible to the fullest extent of the law. Make a Donation Online

Donating is secure and private with PayPal. We accept MasterCard, Visa and American Express. Make a Donation By Mail

Please make checks payable to:
Project Main St.
244 5th Avenue Suite #2417
New York, NY 10001
Honor/Memorial Giving

Your donation is a meaningful way to commemorate a birthday, anniversary, wedding or birth or to send condolences in memory of a loved one. Project Main St. will send an “In Memory” or “In Honor” card will be sent on your behalf to acknowledge the gift. Matching Gifts

Many companies match their employees’ gifts to charity. If you would like you gift to have a even greater impact, just ask your company about matching gift opportunities. Donate Stock

You can help to support Project Main St. by donating appreciated shares of stock, bonds and mutual funds. It’s fast and easy, requiring little paperwork. If you are interested in making a contribution of securities, please call 1-800-965-MAIN. In-Kind Gifts

In-kind gifts are gifts of professional services or goods made directly to Project Main St. If these goods or services are ones that PMS would otherwise have to purchase, the gift may be recognized for tax purposes at the fair market value. Here are just some of the services that Project Main St. needs throughout the year:

Printing Services
Tax Preparation
Items for auction (for are annual gala)

Volunteer

Project Main St. wants your help! Become part of the heart and soul of Project Main St. by donating you time, services or expertise. Volunteers are needed for a variety of activities. For more information on how you can become a part of our volunteer team, please send an email including your contact information to
[email protected]
Link to our Site

If you are interested in assisting Project Main St. with our mission to support individuals and their families who are battling ALS you can do so by linking to our website. You may also right click on the image of our logo and click “Save as..” for a web ready logo which you can use on your site. This logo must link to the home page of our main site and must be used only in a “positive” manner. If you are unsure of usage, please contact [email protected]

Links to: http://www.projectmainst.org
Appropriate for: Websites, HTML Emails
Not appropriate for: Printed Publications

Tell a Friend

At its core, Project Main St. is about neighbors helping neighbors. Word of mouth is essential for a volunteer organization like ours. We rely on our friends and supporters to spread the word about the work that we do and urge you to share our story with as many people as possible. Corporate Sponsorship & Cause Marketing; Philanthropy with a Return on Investment

Companies can make contributions for any amount to support Project Main St.’s mission or a specific program or campaign. Companies can sponsor or co-sponsor specific fundraising events. Special initiatives are one time gifts sought to provide for a specific need such as an emergency grant for a particular individual or family. Businesses can enable their customers to participate by adding a contribution to their purchases. By demonstrating a softer side of your company you will generate customer and employee goodwill. Companies donate budget-alleviating products or services to support the work of Project Main St.. Examples include: printing services, tax preparation, medical supplies, and items to be sold at auction. Through matching gift or payroll deduction programs companies and their employee’s can team up to help support the Project Main St. mission. The connection often enhances employee/employer relations. Companies may donate funds or services through their foundations.

Today on Lou Gehrig Day,  comes together for one cause and one message: END ALS.Thank you to all the players helping us ...
06/02/2026

Today on Lou Gehrig Day, comes together for one cause and one message: END ALS.

Thank you to all the players helping us honor Lou Gehrig’s legacy and supporting ALS families today 💙

For Lou. For every family it touches. Until there’s a cure. 💙
06/01/2026

For Lou. For every family it touches. Until there’s a cure. 💙

Spotted: END ALS shirts making their way around the best ballparks. Get your shirt at the link in our bio 👕🔗🏟️
05/19/2026

Spotted: END ALS shirts making their way around the best ballparks. Get your shirt at the link in our bio 👕🔗🏟️

Did you know Amyotrophic Lateral Sclerosis (ALS) is also known as Lou Gehrig’s disease, named after baseball legend Lou ...
05/13/2026

Did you know Amyotrophic Lateral Sclerosis (ALS) is also known as Lou Gehrig’s disease, named after baseball legend Lou Gehrig (pictured)? He was diagnosed with ALS in 1939 and his public battle brought widespread attention to the disease. June 2 is recognized across MLB as Lou Gehrig Day, a league-wide effort to honor his legacy, raise ALS awareness and support those living with ALS. Get your END ALS shirt at the link in our bio to help support the cause. Wear it on June 2nd.

05/08/2026

Sports media showing up in a big way for ALS awareness month. Match these guys by getting your own END ALS shirt at the link in our bio.

National Sports Day during ALS Awareness Month feels pretty fitting! MLB guys continue to show up for the ALS community ...
05/07/2026

National Sports Day during ALS Awareness Month feels pretty fitting! MLB guys continue to show up for the ALS community in such a big way. Support people living with ALS by getting your own END ALS shirt at the link in our bio 🔗🩵⚾️

MLB Managers supporting Project Main Street for ALS Awareness Month. Did you know … -Someone is diagnosed with ALS about...
05/04/2026

MLB Managers supporting Project Main Street for ALS Awareness Month. Did you know …

-Someone is diagnosed with ALS about every 90 minutes
-The average life expectancy after diagnosis is 2 to 5 years -Many people require 24/7 care as the disease progresses
-The cost of care can exceed hundreds of thousands of dollars

Get your END ALS shirt at the link in our bio to help support those living with ALS. All proceeds go directly to families affected by ALS.

05/02/2026

A simple message, from a lot of important voices: END ALS. May is ALS Awareness month. This month is about awareness, support, and showing up for those living with ALS. Learn more, get involved, and help make a difference. Link to the shirts in bio🔗

keep the cubs wins coming & keep the ALS awareness growing
04/22/2026

keep the cubs wins coming & keep the ALS awareness growing

It’s opening day! ⚾️🧢 New season, same goal: END ALS. 💪🏼👏🏼Get your teams END ALS shirt at the link in our bio 🔗 or donat...
03/26/2026

It’s opening day! ⚾️🧢 New season, same goal: END ALS. 💪🏼👏🏼

Get your teams END ALS shirt at the link in our bio 🔗 or donate to help those living with ALS

Address

244 5th Avenue, Ste 2417
New York, NY
10001

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