Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.

Since its inception in 1896, the goal of The Journal of Experimental Medicine (JEM) has been to publish outstanding and enduring studies in medical biology. At a time when many leading publishing groups are establishing topic-specific journals, we believe it is critical to complement that approach by offering a distinguished venue for publication of studies that integrate disciplines within the fi

eld of pathogenesis. A distinctive editorial system supports this goal with an emphasis on exceptional service to our authors. Two groups of editors work hand-in hand: professional editors with strong scientific backgrounds, and full-time practicing scientists. At least one editor from each group evaluates the merits of each paper prior to external review. The editors convene weekly to discuss all papers with external referee comments, and reach rapid decisions without excessive requests for revision. Within the field of medical biology we focus both on human studies and diverse in vivo experimental models of human disease that address such topics as genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We welcome reports ranging from atomic-level analyses to clinical interventions that illustrate new mechanisms.

Tissue-resident   acquire distinct identities shaped by local signals. Jorge Mínguez-Martínez, Jesús Porcuna, Mercedes R...
06/02/2026

Tissue-resident acquire distinct identities shaped by local signals. Jorge Mínguez-Martínez, Jesús Porcuna, Mercedes Ricote and colleagues (Centro Nacional de Investigaciones Cardiovasculares) show that RXRs drive alveolar macrophage differentiation by regulating chromatin & gene expression in cooperation w other regulatory elements https://hubs.la/Q04jPvXQ0

Irena Roci et al. of the Tatiana V. Petrova lab show that the water channel AQP1 sustains lymphatic endothelial cell mig...
06/01/2026

Irena Roci et al. of the Tatiana V. Petrova lab show that the water channel AQP1 sustains lymphatic endothelial cell migration under osmotic stress, establishing tissue as a key biophysical determinant of postnatal . https://hubs.la/Q04jyvrh0

Marine Bruand, Elisa Oricchio et al. reveal cathepsin S as a regulator of B cell maturation in germinal center reactions...
06/01/2026

Marine Bruand, Elisa Oricchio et al. reveal cathepsin S as a regulator of B cell maturation in germinal center reactions, high-affinity antibody production, and formation of tertiary lymphoid structures. https://hubs.la/Q04jz1wf0

Our June issue is here! https://hubs.la/Q04j66Hv0) The cover image is from a full spleen section of an AID-R112H mouse, ...
06/01/2026

Our June issue is here! https://hubs.la/Q04j66Hv0)
The cover image is from a full spleen section of an AID-R112H mouse, which is devoid of AID activity, 7 days after immunization. From Minghui He, Lisa Westerberg an colleagues: https://hubs.la/Q04j5wx50

Using an unbiased forward mutagenesis screen in an autochthonous mouse model, Francisca Nunes de Almeida, Alessandro Vas...
05/28/2026

Using an unbiased forward mutagenesis screen in an autochthonous mouse model, Francisca Nunes de Almeida, Alessandro Vasciaveo, Arianna Giacobbe, Matteo Di Bernardo, Min Zou et al. of the Abate-Shen and Califano labs have identified new mechanistic determinants of aggressive . SIRT1 emerged as a potential target for therapeutic intervention. https://hubs.la/Q04jcb470

See the accompanying press release: https://hubs.la/Q04jc6Rg0

Researchers at Columbia University have identified a gene that drives the development of neuroendocrine prostate cancer,...
05/28/2026

Researchers at Columbia University have identified a gene that drives the development of neuroendocrine prostate cancer, an aggressive form of the disease.
👉 https://hubs.ly/Q04hZ6mP0

See the original study by the Abate-Shen lab at Columbia University Irving Medical Center:
👉 https://hubs.ly/Q04hYYhH0

In this Viewpoint, Søren Paludan (Aarhus Universitet) and Sara Cherry (Perelman School of Medicine at the University of ...
05/27/2026

In this Viewpoint, Søren Paludan (Aarhus Universitet) and Sara Cherry (Perelman School of Medicine at the University of Pennsylvania) reflect on the recent outbreak and discuss the need for a better understanding of the different phases of viral diseases to improve treatment. https://hubs.la/Q04h_P_40

Although memory and exhausted CD8 T cells arise through distinct differentiation pathways, this study from Xiaonan Ma, M...
05/26/2026

Although memory and exhausted CD8 T cells arise through distinct differentiation pathways, this study from Xiaonan Ma, Min Peng et al. (Tsinghua University) reveals that targeting UBE2F induces a shared resilience program characterized by heightened IL-15 responsiveness and enhanced longevity. https://hubs.la/Q04hS_s_0

Yuki Honda Keith, Tri Giang Phan et al. (Garvan Institute of Medical Research) show that tissue-resident CSF1R-dependent...
05/22/2026

Yuki Honda Keith, Tri Giang Phan et al. (Garvan Institute of Medical Research) show that tissue-resident CSF1R-dependent CD169⁺ localize deep in the skin. They surround growing tumors and directly suppress growth independent of T and B cells. https://hubs.la/Q04hF9Jv0

📰 Researchers at Garvan Institute of Medical Research have captured, for the first time, ‘housekeeping’ immune cells act...
05/22/2026

📰 Researchers at Garvan Institute of Medical Research have captured, for the first time, ‘housekeeping’ immune cells actively attacking and engulfing live cells.
👉 https://hubs.la/Q04hDzc00

Original study in JEM by Keith et al. of the Tri Giang Phan lab:
👉 https://hubs.la/Q04hDSp60

Address

950 3rd Avenue, Fl 2nd
New York, NY
10022

Alerts

Be the first to know and let us send you an email when Journal of Experimental Medicine posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Organization

Send a message to Journal of Experimental Medicine:

Share