Neurosensory Research Foundation

Neurosensory Research Foundation Created to fund research for Hallucinogen Persisting Perception Disorder (HPPD)

08/22/2026

See, it’s all fun and games until it’s not…


This exploratory observational study characterized 13 patients (10 males, mean age 24.3 years) with persistent perceptual disturbances following cannabis or synthetic cannabinoid use. Comprehensive clinical assessments revealed that visual snow was universal (100%), with frequent trailing phenomena (92.3%), halos (84.6%), and color changes (76.9%). A notable novel finding was auditory hypersensitivity in 61.5% of patients. Symptoms typically emerged about 3.2 weeks after cannabis cessation, and all neurological examinations and neuroimaging were normal. Comorbid anxiety was highly prevalent (84.6%), and functional impairment ranged from mild to severe. The authors conclude that this distinct symptom profile—particularly the combination of visual snow, auditory hypersensitivity, and normal neurological findings—suggests a potentially underrecognized complication of cannabis use that warrants further systematic investigation.

A groundbreaking chemogenetic therapy using DREADDs (designer receptors activated by designer drugs) has entered human c...
08/16/2026

A groundbreaking chemogenetic therapy using DREADDs (designer receptors activated by designer drugs) has entered human clinical trials in China, marking a major milestone for the field. Developed twenty years ago by Bryan Roth of UNC, the technique uses a viral vector to introduce a designer receptor gene into specific neurons, which then suppresses neuronal activity when triggered by a small-molecule drug. At least seven trials are now underway targeting intractable epilepsy, Parkinson's disease, and neuropathic pain—conditions that currently may require invasive brain surgery. The news, shared at a U.S. NIH BRAIN Initiative meeting, left American neuroscientists "stunned," with some noting that China has taken a clear lead in this area of neurotechnology. While the approach offers greater precision and potentially fewer side effects than traditional drugs, it carries risks common to viral-vector gene therapies, including severe immune reactions. Nevertheless, researchers believe that if successful, the therapy could pave the way for circuit-based treatments for a wide range of neuropsychiatric diseases.

Chinese researchers are testing DREADDs, a gene therapy to turn down neuronal activity, in the clinic

08/15/2026

This message was recorded in 1992, yet it feels just as powerful to...

08/15/2026

A new psychedelic survey from UCL is seeking to understand how psychedelics and related drugs affect different people across the lifespan.

See details and the link to contribute your experience to psychedelic research below:

https://qualtrics.ucl.ac.uk/jfe/form/SV_a44pPupnpjzL5ie

08/15/2026

Did you know the first documented mention of visual snow appeared in the medical literature over 80 years ago?

🗓️ In 1944, Dr. Frank D. Carroll described patients experiencing persistent visual disturbances, including “snowy vision,” flashing and flickering lights, colored floaters, and other visual phenomena. Although their eye examinations were normal, he proposed that these symptoms originated in the brain rather than the eyes.
This early report marked the beginning of what would eventually become our understanding of Visual Snow Syndrome.

Explore our new Timeline of Visual Snow Syndrome and the Visual Snow Initiative to discover the history of VSS and the key milestones in research, advocacy, recognition, and awareness that have shaped the field over the decades.

https://www.visualsnowinitiative.org/vss-timeline/

08/14/2026
Everyone using   drugs or working in   should be doing all they can to support funding and research for Hallucinogen Per...
08/14/2026

Everyone using drugs or working in should be doing all they can to support funding and research for Hallucinogen Persisting Perception Disorder.

Here’s the connection:* The new work argues that color perception follows a precise internal geometric structure created...
05/11/2026

Here’s the connection:

* The new work argues that color perception follows a precise internal geometric structure created by neural processing.
* HPPD symptoms — visual snow, trailing, halos, intensified colors, afterimages, pattern glare, derealization — suggest that this internal visual processing geometry becomes dysregulated.
* In HPPD, the brain may fail to properly stabilize or suppress sensory information, causing perception to become overly “raw,” noisy, or unstable.

One possible implication:
normal brains continuously “normalize” visual input so colors, motion, brightness, and contrast remain coherent. HPPD may involve partial breakdown of those normalization systems.

Examples:

* Brightness changes may distort color perception excessively.
* Contrast edges may become hyper-salient.
* Afterimages may persist because inhibitory networks fail to dampen visual persistence.
* Visual snow may reflect spontaneous cortical noise overwhelming filtering systems.

This overlaps with current theories involving:

* thalamocortical dysrhythmia
* impaired GABAergic inhibition
* visual cortex hyperexcitability
* dysfunctional predictive coding/network filtering

Researchers studying disorders like Visual Snow Syndrome and HPPD increasingly think the problem is not isolated to one brain region, but to distributed visual-processing networks. That aligns with this new color-geometry work because it also treats perception as an emergent property of coordinated neural computations rather than simple retinal input.

The study could indirectly help future HPPD research in a few ways:

* Better mathematical models of subjective perception
* More precise measurement of perceptual distortions
* Improved computational models of visual cortical processing
* Potential biomarkers for altered perceptual states

But it is important to separate:

* fundamental perception theory
from
* therapeutic intervention research.

This paper does not provide a treatment pathway for HPPD, nor does it directly explain why hallucinogens can trigger persistent perceptual changes.

The more clinically relevant overlap is with modern network neuroscience approaches — especially work by researchers studying:

* cortical oscillations
* sensory gating
* thalamocortical loops
* predictive coding failures
* functional connectivity abnormalities

That is why efforts like neuromodulation, TMS, neurofeedback, and network-targeted therapies are attracting attention in HPPD and VSS research.

Scientists have finally cracked the hidden geometry behind how humans perceive color.

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