06/18/2026
New Endo Society guidelines on CPP management:
Key updates:
1. Watchful Waiting Over Immediate Workup for Girls Ages 7–8 with Early Thelarche
2. Basal Ultrasensitive LH Replaces Routine GnRH Stimulation Testing- can use these guidelines to support auth in patients as needed.
3. Reduced Indications for Brain MRI
4. Clinical Monitoring Over Routine Biochemical Testing During GnRHa Treatment
5. Start with the Long-Term Formulation and Defined Stopping Rules
6. Suggesting against routine addition of growth hormone to GnRHa therapy to increase adult height, and suggesting against routine genetic testing
AbstractBackground. Central precocious puberty (CPP), which is traditionally defined as the development of secondary sexual characteristics before age 8 ye