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International Society for Computational Biology - ISCB ISCB is a scholarly society representing computational biology and bioinformatics worldwide.

Principal Component Analysis underpins population structure inference and GWAS quality control, but modern biobank-scale...
10/21/2026

Principal Component Analysis underpins population structure inference and GWAS quality control, but modern biobank-scale genotype data has outgrown single-node computing. DistPCA is a distributed C++ framework built on MPI that combines multi-level parallelism across the I/O, preprocessing, and numerical stages of out-of-core PCA. Tested on datasets up to 1 million individuals and 6 million SNPs, it achieved near-linear scaling and cut wall-clock time by over 80% compared to PCAone, the prior state of the art.

Read the full paper here: https://doi.org/10.1093/bioadv/vbag303

๐Ÿ‡ต๐Ÿ‡ช ISCB LATAM 2026 is happening soon!Join researchers from Latin America for 5 days of talks, posters, keynotes, and ne...
10/21/2026

๐Ÿ‡ต๐Ÿ‡ช ISCB LATAM 2026 is happening soon!

Join researchers from Latin America for 5 days of talks, posters, keynotes, and networking opportunities!

โžก๏ธ Register here: https://www.iscb.org/latam2026/register

๐Ÿ“ฃSubmit your proposal for a hands-on bioinformatics tutorial to GLBIO 2027!Share your expertise and help participants bu...
10/21/2026

๐Ÿ“ฃSubmit your proposal for a hands-on bioinformatics tutorial to GLBIO 2027!

Share your expertise and help participants build practical skills while exploring new or emerging research areas.

๐Ÿ“… Deadline: Thursday, November 19, 2026

To learn more about tutorial proposal submissions, visit https://www.iscb.org/glbio2027/call-for-submissions/tutorials

How does Fusobacterium nucleatum, a gut bacterium linked to colorectal cancer, encode its pathogenic potential? Rather t...
10/21/2026

How does Fusobacterium nucleatum, a gut bacterium linked to colorectal cancer, encode its pathogenic potential?

Rather than classic horizontally-acquired pathogenicity islands, this study found three vertically-inherited genomic regions handling cytotoxicity, metabolic adaptation, and colonization, broadly conserved across 15 Fusobacterium genomes. Genome-scale metabolic modeling showed iron is essential for growth, with complete deprivation halting it entirely. AlphaFold3 structural validation and co-expression analysis support a hypothesized hemolysin-driven, iron-dependent signaling route to oncogenesis.

Explore the full study at https://doi.org/10.1093/bioadv/vbag302

The odorant receptor co-receptor Orco is essential for mosquito olfaction and a promising target for disrupting malaria-...
10/20/2026

The odorant receptor co-receptor Orco is essential for mosquito olfaction and a promising target for disrupting malaria-spreading behavior, but how it opens and closes was unclear at the structural level. Using molecular dynamics simulations on homology-built and AlphaFold3 models of the Anopheles gambiae Orco homotetramer, researchers found that only the template-based model correctly reproduced agonist-induced pore opening seen experimentally, showing asymmetric widening upon VUAA1 binding. The antagonist IPC kept the pore closed and could reverse an agonist-opened pore even at low relative concentration. These findings support template-based modeling as the more reliable framework for designing new Orco-targeting repellents and vector-control agents.

Find the full paper at https://doi.org/10.1093/bioadv/vbag295

๐ŸŒŸ Nominate an ISCB Fellow! ๐ŸŒŸSince 2009, the ISCB Fellows Program has celebrated members who are advancing the field of c...
10/20/2026

๐ŸŒŸ Nominate an ISCB Fellow! ๐ŸŒŸ

Since 2009, the ISCB Fellows Program has celebrated members who are advancing the field of computational biology and bioinformatics through their research, service, and leadership. Be part of this tradition and submit your nomination for the next ISCB Fellows class member today!

To submit a nomination, log in to your ISCB account and visit https://www.iscb.org/about-iscb/fellows

๐Ÿ—“๏ธ Nominations close January 21, 2027

10/20/2026

๐Ÿ“…๐Œ๐š๐ซ๐ค ๐˜๐จ๐ฎ๐ซ ๐‚๐š๐ฅ๐ž๐ง๐๐š๐ซ๐ฌ ๐Ÿ๐จ๐ซ ๐ˆ๐’๐…๐Œ๐’ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ• ๐ข๐ง ๐๐š๐ซ๐œ๐ž๐ฅ๐จ๐ง๐š, ๐’๐ฉ๐š๐ข๐ง!

Following a successful last edition of ISFMS 2025 in Kyoto, Japan, we are delighted to announce that the ๐Ÿ”๐ญ๐ก ๐ˆ๐ง๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐’๐ฒ๐ฆ๐ฉ๐จ๐ฌ๐ข๐ฎ๐ฆ ๐จ๐ง ๐…๐ซ๐จ๐ง๐ญ๐ข๐ž๐ซ๐ฌ ๐ข๐ง ๐Œ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐’๐œ๐ข๐ž๐ง๐œ๐žยญยญโ€”๐“๐ซ๐ž๐ง๐๐ฌ ๐ข๐ง ๐๐ข๐จ๐œ๐ก๐ž๐ฆ๐ข๐ฌ๐ญ๐ซ๐ฒ ๐š๐ง๐ ๐Œ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐๐ข๐จ๐ฅ๐จ๐ ๐ฒ (๐ˆ๐’๐…๐Œ๐’ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ•) will take place ๐Ÿ๐Ÿ’โ€“๐Ÿ๐Ÿ• ๐’๐ž๐ฉ๐ญ๐ž๐ฆ๐›๐ž๐ซ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ• in ๐๐š๐ซ๐œ๐ž๐ฅ๐จ๐ง๐š, ๐’๐ฉ๐š๐ข๐ง.



ISFMS 2027 will bring together leading researchers and emerging scholars across these ๐Ÿ๐ŸŽ ๐œ๐ฎ๐ญ๐ญ๐ข๐ง๐ -๐ž๐๐ ๐ž sessions:



S1. Protein Structure and Dynamics

S2. Enzymes

S3. Molecular & Cellular Mechanisms of Disease (Cancer, Autophagy, Immunity)

S4. Genetics, Genomics, Epigenetics, and Gene Regulation (including ncRNA)

S5. Biomarkers, Molecular Diagnostics, and Precision Medicine

S6. Drug Discovery, Design, and Molecular Therapeutics

S7. Bioactive Compounds, Nutraceuticals, and Molecular Nutrition

S8. Multi-Omics and Systems Biology Approaches

S9. Artificial Intelligence and Computational Molecular Science

S10. Biochemical Basis of Neurodegenerative Diseases



๐ƒ๐จ๐งโ€™๐ญ ๐Œ๐ข๐ฌ๐ฌ ๐ญ๐ก๐ž ๐‚๐ก๐š๐ง๐œ๐ž!

- Engage with our international community of experts

- Exchange ideas at the forefront of innovation.

- Present your latest research to peers



๐Ÿ“Œ๐€๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ ๐’๐ฎ๐›๐ฆ๐ข๐ฌ๐ฌ๐ข๐จ๐ง ๐ƒ๐ž๐š๐๐ฅ๐ข๐ง๐ž: 14 May 2027



๐Ÿ”— ๐‹๐ž๐š๐ซ๐ง ๐ฆ๐จ๐ซ๐ž ๐š๐›๐จ๐ฎ๐ญ ๐ˆ๐’๐…๐Œ๐’ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ•:

https://brnw.ch/21x3TUg



We look forward to welcoming you to Barcelona for an inspiring and collaborative conference.

Standard microbiome differential abundance analysis looks only at taxonomy, missing the fact that different microbes can...
10/20/2026

Standard microbiome differential abundance analysis looks only at taxonomy, missing the fact that different microbes can perform the same function and that unknown microbes also contribute to that function. TSLC is a new two-stage method that first identifies differentially abundant functions, then pinpoints which known microbes are significantly associated with them, using penalized log-contrast models to handle the compositional nature of microbiome data. In simulations, TSLC consistently outperformed FishTaco and standard taxonomic approaches while being the only method to control the false discovery rate. Applied to oral microbiome and inflammatory bowel disease datasets, TSLC identified biologically relevant microbes that differed substantially from those found by conventional one-stage analysis.

Access the full paper at https://doi.org/10.1093/bioadv/vbag297

Picking the right pre-trained model for protein engineering is often guesswork, especially for non-experts without machi...
10/19/2026

Picking the right pre-trained model for protein engineering is often guesswork, especially for non-experts without machine learning expertise. PRIZM solves this with a two-phase workflow: first using a small existing dataset of as few as 20 labeled variants to identify which of 25 zero-shot models best predicts a target protein property, then applying that model to rank a full variant library for testing. Validated across ten benchmark datasets, PRIZM reliably distinguished strong from weak models. In two enzyme engineering case studies, it found variants with a ~3ยฐC higher melting temperature and ~20% greater relative activity, reusing pre-existing low-N data rather than requiring new experiments.

Read more at https://doi.org/10.1093/bioadv/vbag299

๐Ÿคจ Have you submitted your paper to GLBIO?We're inviting paper submissions that showcase original, unpublished research t...
10/19/2026

๐Ÿคจ Have you submitted your paper to GLBIO?

We're inviting paper submissions that showcase original, unpublished research that's sharing new discoveries and helping advance the field of bioinformatics!

If you're looking for an opportunity to share your work and get real-time feedback, submitting to the GLBIO Proceedings is the answer!

๐Ÿ—“๏ธ Deadline: Thursday, January 7, 2027

๐Ÿ”— Find all the details on GLBIO Proceedings submissions, key dates, and how to submit here: https://www.iscb.org/glbio2027/call-for-submissions/proceedings

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