05/21/2026
A New Blood Test for Colon Cancer Screening — Progress with Important Limitations
Colorectal cancer is the 3rd most common cancer in both men and women in the U.S. Each year, approximately 150,000 Americans are diagnosed and nearly 53,000 lose their lives to this disease. The good news? Colon cancer is one of the most preventable cancers through screening.
A newly FDA-approved blood-based screening test offers another option for average-risk adults age 45+ who are reluctant to undergo traditional screening.
Here’s what patients should know:
🔹 The blood test detected about 83% of colorectal cancers overall
🔹 Detection of early Stage I cancer was only ~55%
🔹 Detection of advanced precancerous polyps was only ~13%
🔹 By comparison, colonoscopy detects over 95% of colorectal cancers and can remove polyps before they become cancer
This means blood testing may help increase screening participation—but it is not a replacement for colonoscopy. Any positive blood test still requires a follow-up colonoscopy.
At Citrus Colorectal Cancer Foundation, our message remains clear:
The best screening test is the one that gets done—but colonoscopy remains the gold standard for prevention.
Screening starts at age 45 for average-risk adults. Early detection saves lives.