International Brain Research Foundation

International Brain Research Foundation A medical research organization (501C3) that helps those suffering from brain injury, coma, and neurological disorders.

A medical research organization that is registered as not-for-profit (501C3). The IBRF uses innovative treatments to help those suffering from Traumatic Brain Injury recover. They also are on the cutting edge of research for Autism Spectrum and neurological disorders and ailments.

September 2013 Philip A Defina Rosemarie Scolaro Moser Megan Glenn Jonathan Fellus ...and others. ABSTRACT: Of the appro...
07/09/2018

September 2013 Philip A Defina Rosemarie Scolaro Moser Megan Glenn Jonathan Fellus ...and others. ABSTRACT: Of the approximately 6.8 million Americans who have been diagnosed with dementia, over 5 million have been diagnosed with Alzheimer's Disease (AD). Due to the rise in the aging population, these figures are expected to double by 2050. The following paper provides an up-to-date review of clinical issues and relevant research. [ 80 more words ]

September 2013 Philip A Defina Rosemarie Scolaro Moser Megan Glenn Jonathan Fellus …and others. ABSTRACT: Of the approximately 6.8 million Americans who have been diagnosed with dementia, ove…

June 2013 Calixto Machado Jesús Pérez Néllar Rafael Rodriguez-Rojas Mauricio Chinchilla Philip A. DeFina ...and others. ...
07/09/2018

June 2013 Calixto Machado Jesús Pérez Néllar Rafael Rodriguez-Rojas Mauricio Chinchilla Philip A. DeFina ...and others. ABSTRACT: We report unusual twisting of the brainstem in MRI tractography in a patient who survived a traumatic brain injury with upper spinal dislocation. A 39-year-old male patient involved in a high-speed car accident was admitted in coma on February 2003. He had a Glasgow Coma Scale of 4, respiratory arrhythmia and tetraplegia. [ 265 more words ]

June 2013 Calixto Machado Jesús Pérez Néllar Rafael Rodriguez-Rojas Mauricio Chinchilla Philip A. DeFina …and others. ABSTRACT: We report unusual twisting of the brainstem in MRI tractography…

January 2014 Philip A Defina Jonathan Fellu Christine Carson Mauricio Chinchilla ...and others. ABSTRACT: Recent prevale...
07/09/2018

January 2014 Philip A Defina Jonathan Fellu Christine Carson Mauricio Chinchilla ...and others. ABSTRACT: Recent prevalence estimates of pseudobulbar affect (PBA) symptomatology secondary to traumatic brain injury (TBI) exceed 55%. Treatment with dextromethorphan/quinidine (DMQ) has been shown to robustly diminish the frequency and severity of PBA episodes associated with different neurological conditions. Objective. This retrospective case study aims to demonstrate the efficacy of DMQ to minimize PBA symptoms in a series of patients with traumatic brain injury (TBI) and describe unforeseen evidence of its additional therapeutic potential to mitigate diverse neuropsychiatric sequelae. [ 158 more words ]

January 2014 Philip A Defina Jonathan Fellu Christine Carson Mauricio Chinchilla …and others. ABSTRACT: Recent prevalence estimates of pseudobulbar affect (PBA) symptomatology secondary to tr…

August 2013 Rafael Rodriguez-Rojas Calixto Machado Lazaro M Alvarez Philip A Defina ...and others. ABSTRACT: Introductio...
07/09/2018

August 2013 Rafael Rodriguez-Rojas Calixto Machado Lazaro M Alvarez Philip A Defina ...and others. ABSTRACT: Introduction: Zolpidem is a non-benzodiazepine drug used for the therapy of insomnia, which has selectivity for stimulating the effect of GABA-A receptors. Recently, a paradoxical arousing effect of zolpidem in patients with severe brain damage has been repeatedly reported. Methods: A placebo-controlled magnetic resonance study was conducted to evaluate its effect on BOLD and metabolites spectral signals in a patient with severe brain injuries and an age-matched healthy volunteer. [ 142 more words ]

August 2013 Rafael Rodriguez-Rojas Calixto Machado Lazaro M Alvarez Philip A Defina …and others. ABSTRACT: Introduction: Zolpidem is a non-benzodiazepine drug used for the therapy of insomnia…

October 2012 Yazmina Machado-Ferrer Mario Estévez Calixto Machado Yanín Machado Philip A. DeFina ...and others. ABSTRACT...
07/09/2018

October 2012 Yazmina Machado-Ferrer Mario Estévez Calixto Machado Yanín Machado Philip A. DeFina ...and others. ABSTRACT: OBJECTIVE: To assess the autonomic nervous system (ANS) in coma by heart rate variability (HRV). METHODS: Sixteen comatose patients and 22 normal subjects with comparable ages and genders were studied. Patients were classified in two subgroups according to the Glasgow Coma Scale (GCS). [ 160 more words ]

October 2012 Yazmina Machado-Ferrer Mario Estévez Calixto Machado Yanín Machado Philip A. DeFina …and others. ABSTRACT: OBJECTIVE: To assess the autonomic nervous system (ANS) in coma by hear…

January 2012 Daniel C. Miller Philip A Defina ABSTRACT: Translating Brain Research Into Educational Practice. The Role o...
07/09/2018

January 2012 Daniel C. Miller Philip A Defina ABSTRACT: Translating Brain Research Into Educational Practice. The Role of Genetics on Educational Practice. The Role of Brain Imaging in Educational Practice. What Lies Ahead for the Brain Research-Education Linkage? Click here for a link to the PDF. # # #

January 2012 Daniel C. Miller Philip A Defina ABSTRACT: Translating Brain Research Into Educational Practice. The Role of Genetics on Educational Practice. The Role of Brain Imaging in Educational …

March 2011 Max J Hilz Philip A Defina Stefan Anders Harald Marthol ...and others. ABSTRACT: Long-term mortality is incre...
07/09/2018

March 2011 Max J Hilz Philip A Defina Stefan Anders Harald Marthol ...and others. ABSTRACT: Long-term mortality is increased after mild traumatic brain injury (mTBI). Central cardiovascular-autonomic dysregulation resulting from subtle, trauma-induced brain lesions might contribute to cardiovascular events and fatalities. We investigated whether there is cardiovascular-autonomic dysregulation after mTBI. In 20 mTBI patients (37±13 years, 5-43 months post-injury) and 20 healthy persons (26±9 years), we monitored respiration, RR intervals (RRI), blood pressures (BP), while supine and upon standing. [ 192 more words ]

March 2011 Max J Hilz Philip A Defina Stefan Anders Harald Marthol …and others. ABSTRACT: Long-term mortality is increased after mild traumatic brain injury (mTBI). Central cardiovascular-aut…

January 2016 Philip A Defina James P Halper Jonathan Fellus Charles J Prestigiacomo ...and others. ABSTRACT: The purpose...
07/03/2018

January 2016 Philip A Defina James P Halper Jonathan Fellus Charles J Prestigiacomo ...and others. ABSTRACT: The purpose of this paper is to present a novel approach to promoting brain neuroplasticity through the application of neuromarker driven neuro- modulation. A tripartite model utilizing structural, electromagnetic, and neurochemical modalities to identify and localize neuromarkers and then to create personalized, tailored interventions are described. [ 69 more words ]

January 2016 Philip A Defina James P Halper Jonathan Fellus Charles J Prestigiacomo …and others. ABSTRACT: The purpose of this paper is to present a novel approach to promoting brain neuropla…

June 2013 Project: PVS / MCS Philip A. Defina Rafael Rodriguez-RojasRafael Batista García-Ramó Yasser Iturria Maylen Car...
07/03/2018

June 2013 Project: PVS / MCS Philip A. Defina Rafael Rodriguez-RojasRafael Batista García-Ramó Yasser Iturria Maylen Carballo-Barreda ...and others. ABSTRACT: Background: Persistent vegetative states (PVS) and locked-in syndrome (LIS) are well differentiated disorders of consciousness that can be reached after a localized brain injury in the brainstem. The relations of the lesion topography with the impairment in the whole-brain architecture and functional disconnections are poorly understood. [ 158 more words ]

June 2013 Project: PVS / MCS Philip A. Defina Rafael Rodriguez-RojasRafael Batista García-Ramó Yasser Iturria Maylen Carballo-Barreda …and others. ABSTRACT: Background: Persistent vegetative …

September 2013 Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-013-1909-5 SourcePubMed Project: Autism...
07/03/2018

September 2013 Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-013-1909-5 SourcePubMed Project: Autism Philip A. DeFina Calixto Machado Mario Estévez Gerry Leisman Carlos Beltrán ...and others. ABSTRACT: We studied autistic people by quantitative EEG spectral and coherence analysis during three experimental conditions: basal, watching a cartoon with audio (V-A), and with muted audio band (VwA). Significant reductions were found for the absolute power spectral density (PSD) in the central region for delta and theta, and in the posterior region for sigma and beta bands, lateralized to the right hemisphere. [ 67 more words ]

September 2013 Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-013-1909-5 SourcePubMed Project: Autism Philip A. DeFina Calixto Machado Mario Estévez Gerry Leisman Carlos Beltrán …

January 2015 DOI: 10.13140/RG.2.1.3372.5520 Conference: Premio Anual de Salud 2014: Heart rate variability for assessing...
07/03/2018

January 2015 DOI: 10.13140/RG.2.1.3372.5520 Conference: Premio Anual de Salud 2014: Heart rate variability for assessing comatose patients with different Glasgow Coma Scale scores Project: Autism Philip A. DeFina Yazmina Machado-Ferrer Mario Estévez Mario Estévez Calixto Machado Calixto Machado ...and others. ABSTRACT: Objective: to assess the autonomic nervous system (ANS) in coma by heart rate variability (HRV). Methods: Sixteen comatose patients and 22 normal subjects with comparable ages and genders were studied. [ 172 more words ]

January 2015 DOI: 10.13140/RG.2.1.3372.5520 Conference: Premio Anual de Salud 2014: Heart rate variability for assessing comatose patients with different Glasgow Coma Scale scores Project: Autism P…

April 2018 Conference: American Academy of Neurology At: Los Angeles, California, USA Project: Autism Philip A Defina Ya...
07/03/2018

April 2018 Conference: American Academy of Neurology At: Los Angeles, California, USA Project: Autism Philip A Defina Yanin Machado Mauricio Chinchilla Yazmina Machado ...and others. ABSTRACT: Objective: To determine the relationship between the anatomic (AC) vs. functional (FC) connectivity, considering short-range and long-range brain networks. Background: In a recent published paper (Machado et al., 2013), we showed that in autistics studied with video without audio tasks vs. [ 252 more words ]

April 2018 Conference: American Academy of Neurology At: Los Angeles, California, USA Project: Autism Philip A Defina Yanin Machado Mauricio Chinchilla Yazmina Machado …and others. ABSTRACT: …

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