N of One: Autism Research Foundation

09/24/2025

Leucovorin (Folinic Acid) has been in the news recently as a possible treatment for autism, however this is not new. It has been used by some doctors for years. Here is an interview 2016 we did with Dr. Richard Frye about their double-blind, placebo controlled trial that gives a good overview of the subject.

As part of N of One's ongoing series to connect you directly to researchers, Dr. Richard Frye answers questions about his autism trial using folinic acid.

05/10/2024

Jim Simon's contribution to autism research is without parallel. He spent billions working to unravel the underpinnings of autism and leaves behind an institution that continues to support programs and researchers working to that goal.

I will always remember him for his kindness and inviting N of One to come share ideas about how to accelerate progress in autism research.

Rest in Peace Jim Simons.

Simons Foundation Co-Founder, Mathematician and Investor Jim Simons Dies at 86 on Simons Foundation

12/26/2023

Harvard Business School profiles Founder John Rodakis’ efforts to reshape the field autism research in the pursuit of breakthroughs. https://www.alumni.hbs.edu/stories/Pages/story-impact.aspx?num=9331

12/23/2023

A huge thank you to Dedication Minerals for raising over $10k for autism research by auctioning thousands of dollars worth of their beautiful crystals and minerals and donating ALL of the proceeds to N of One.

Many of these items could be in a museum. You can check them out on Instagram dedication.minerals or www.dedicationsavannah.com. Many thanks to Nick and his team for their generous holiday act.

N of One: Autism Research Foundation is a non-profit that sponsors breakthrough autism research.
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09/21/2023

Today is N of One's one-day, annual fundraiser. We have $20,000 in matching funds available.

Please consider supporting and helping us find breakthroughs for autism. 100% of donations goes to research.

PS - Liking this post doesn't mean you have to donate, but it does help it reach more people! 😉

$20,000.00 MATCH AVAILABLE!(Through midnight Thur. Sept. 22)N of One was founded by parents and researchers who believe that breakthroughs in autism research that will lead to treatments and prevention strategies are possible in our lifetime.Autism is now affecting 1 in 36...

06/29/2023

While there has been growing evidence of a link between Autism and the gut microbiome over the years, there have occasionally been researchers who suggest that the link wasn't there.

Recently a group of brilliant researchers re-analyzed the naysayers work and found that mistakes were made, and validated a strong link seen across dozens of studies.

Importantly, this work was funded by the Simon's Foundation, the largest private funder of ASD research in the world.

A SFARI initiated and funded reanalysis of previous studies reveals consistent biological signals in the human microbiome and other physiological signals associated with autism and highlights the need for long-term studies to determine autism’s underlying causes.

04/27/2023

One of N of One's major focus areas is the microbiome. While this is not for ASD, it is notable as the first FDA approval for a pill-based microbiome treatment.

We continue to wait for results from the ASD trials now wrapping up at Arizona State.

The therapy opens the door to future treatments that may restore healthy bacteria in the body

09/22/2022

$20,000.00 Donation match for Autism research till Midnight tonight!

Thanks to those who have already given. We have already raised $10k, but still have a ways to go. Come see how we are doing. It feels good to give even a small amount 😊

$20,000.00 MATCH AVAILABLE!(Through midnight Thur. Sept. 22)N of One was founded by parents and researchers who believe that breakthroughs in autism research that will lead to treatments and prevention strategies are possible in our lifetime.Autism is now affecting 1 in 44...

09/14/2022

New N of One Supported Research Points Toward Three Autism Sub-groups with Distinct Prenatal Risk Factors

“Autism has always been diagnosed as one condition.” said Dr. Hahn, the study's author, “Now this work not only shows that there are subgroups of children with different co-occurring conditions, but that there are different prenatal risk factors associated with these subgroups. may not be sufficient in the future.”

The research found that infections, anti-inflammatory, and other complex medications were associated with one of the groups while immune disregulatory conditions such as asthma and joint disorders were associated with the second group, and lastly, overall pregnancy complications were associated with the third group of children.

pspanspanspanspanAutism Spectrum Disorder (ASD) is a “blanket” diagnosis applied to individuals with vastly differing behavioral as well as co-occurring medical conditions.  Using very large medical-record data sets, researchers from Rensselaer Polytechnic Institute (RPI) have found that, not o...

06/24/2022

New Research from N of One Scientific Advisors and Collaborators: Dr. Judy Van de Water & Dr. Ale Ramirez.

It’s important to understand that these types of antibodies are only found in a small number of cases. Much more research to come in this important area.

N of One has a multi-year project underway with this same team examining auto-antibodies in CHILDREN with ASD. More to come..

The reactivity of a mother’s autoantibodies to specific fetal brain protein patterns can predict a child’s diagnosis with a type of autism known as MAR ASD. MAR ASD was present in around 20% of autistic kids in samples from Arkansas and Philadelphia and was linked to significant autistic traits....