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Cold Spring Harbor Laboratory Press

Cold Spring Harbor Laboratory Press publishes celebrated books, journals and other media in the fields of genetics, cell and molecular biology.

Revenue from these publications supports scientific research at Cold Spring Harbor Laboratory.

05/21/2026

RNA function depends on interaction networks that are far more complex than individual protein–RNA contacts alone.

This new review from the examines the latest CLIP-based methods for profiling protein–RNA and protein-associated RNA–RNA interactions, including approaches that help reconstruct RNA interaction networks across the transcriptome.

The paper highlights both the progress and ongoing challenges in mapping these interactions, offering researchers a practical framework for studying RNA-binding proteins and RNA regulatory systems at scale.

Read the review here: bit.ly/41KDfWl

05/19/2026

Machine learning is transforming RNA secondary structure prediction.

This review in the explores how deep learning and other AI approaches are reshaping RNA structure prediction—while also highlighting the challenges researchers still face when predicting unfamiliar RNA structures.

The article also looks ahead to future hurdles, including modeling more complex and dynamic RNA structures. Read more: bit.ly/4spSj6s

05/07/2026

Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing

A new review from the highlights how nanopore direct RNA sequencing (DRS) is advancing the study of the epitranscriptome by allowing researchers to directly analyze RNA modifications and RNA damage with long-read sequencing technology.

The article explores emerging applications, current technical challenges, and future opportunities for understanding RNA biology at transcriptome scale.

Read more: bit.ly/3POaGo9

05/04/2026

What’s next for RNA biology at system scale? In this editorial, the editors frame a shift toward quantitative, integrative approaches, highlighting advances in measuring, modeling, and ultimately manipulating RNA across biological systems. http://bit.ly/41hv9UJ

04/30/2026

We’re pleased to share the new RNA Special Issue:
System-level measurement, modeling, and manipulation of RNA

This collection brings together perspectives from leaders in the field, and showcases advances in system-level RNA biology—from epitranscriptomics and RNA damage to deep learning–driven structure prediction and beyond.

These contributions highlight how large-scale measurement, computational modeling, and emerging technologies are transforming our ability to understand—and ultimately predict—RNA behavior across biological systems.

Over the coming weeks, we’ll be highlighting each article from the issue. Explore the Special Issue here: https://bit.ly/RNAspecialissue2026

03/08/2026

On International Women’s Day, we celebrate women whose courage and determination have changed the course of science—and countless lives.

For more than four decades, Dr. Nancy Wexler has been at the forefront of the fight against Huntington’s disease. After learning as a young woman that her mother’s illness was Huntington’s—and that she herself had a 50% chance of inheriting it—Wexler turned that knowledge into a lifelong mission.

Her groundbreaking work helped lead to the discovery of the gene responsible for Huntington’s disease, a milestone that transformed research on the condition and opened the door to genetic testing and new approaches to treatment. Along the way, she built bridges between scientists, patients, policymakers, and families affected by the disease, showing how deeply personal commitment can drive scientific progress.

Today we honor Nancy Wexler not only for her scientific achievements, but for the compassion, persistence, and leadership she has brought to the global effort to understand and combat Huntington’s disease.

Her memoir, My Life, My Science, sharing the remarkable story behind that journey, will be released this Tuesday, available on Amazon the CSHL Press website.

03/04/2026

The new issue of is now live. Follow the link to new research on chromosome engineering in 8p syndrome, convergent evolution in arid rodents, and more! https://tinyurl.com/Genome-Res-36-3

03/02/2026

Huntington’s disease (HD) is a rare, fatal, genetic disorder that causes progressive breakdown of nerve cells in the brain, deteriorating a person’s physical and mental abilities usually beginning between ages 30 and 50.

It leads to devastating physical, cognitive, and psychiatric symptoms — including involuntary “dance-like” movements (chorea), dementia, and profound personality changes.

Cold Spring Harbor Laboratory’s 2019 Double Helix Medal honoree, Nancy Wexler, learned at 23 that she was at risk for Huntington’s disease. She turned that moment into a life’s mission — leading groundbreaking research in a Venezuelan community that helped identify the HD gene mutation and paved the way for today’s genetic test.

Coming March 10 from Cold Spring Harbor Laboratory Press, renowned geneticist Nancy Wexler shares her extraordinary personal and scientific journey in "My Life, My Science: Pursuing a Cure for Huntington’s Disease".

A powerful story of persistence, discovery, and hope. Available for pre-order from Amazon now: https://amz.cx/3c1w

Because breakthroughs in rare disease begin with basic biology.

02/06/2026

The new issue of Genome Research is now live. Follow the link to new research on transposable elements in pancreatic cancer, genomic evolution in living fossils, and more! https://tinyurl.com/Genome-Res-36-2

11/05/2025

Join us for a special book signing on Thursday, Nov. 6 from 5:00–5:30 PM in Grace Lobby at Cold Spring Harbor Laboratory.
Meet Helen Blau, author of Stem Cells to the Rescue! Helen Blau is a cell biologist and stem cell researcher renowned for her work on muscle diseases, regeneration and aging.
Get this engaging children’s book for just $10 — a great gift to inspire the next generation of scientists.

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