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Brain-Body Research Institute

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Brain-Body Research Institute

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Our mission is to engage in advanced research and education on communication between the nervous and immune systems.

Our ultimate goal is to achieve translation of our research findings into new treatments for neurological disorders. Research Overview
The founding scientific team, pioneers in the field of neuroimmunology, has over the last 30 years made major discoveries in the role of an inflammatory protein in brain functioning. In the clinical setting, they have observed that blocking this protein has profound effects on many pathologies, demonstrating a primary mechanism that can be targeted for treatment of pathologies including:

Neuropathic Pain
Traumatic Brain Injury (TBI)
Stroke
Alzheimer’s
Huntington’s
Cerebral Palsy
Complex regional pain syndrome (CRPS)

In addition to observations in the clinical setting, this scientific team has also published pre-clinical research defining this primary mechanism as a therapeutic target in these additional pathologies:

Diabetic Neuropathy
Concussion
Chronic Pain
Depression

These discoveries in neuroimmunology amount to a paradigm shift in understanding of brain dysfunction. The public will only benefit from these discoveries when they are translated into effective treatments and prevention methods for the above dysfunctions. This is what we are committed to achieve at the Brain-Body Research Institute.

10/14/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery: Improved Spasticity & Numbness after PSE Treatment at INR

Rapid improvement in spasticity, numbness, pain, and fatigue after PSE stroke treatment by Danielle Ucci, PA-C over 1 year after stroke. Filmed on July 7, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/C0_OFSF9n7Q

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.inrmed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in spasticity, numbness, pain, and fatigue after ...

10/07/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Rapid Improvement in Pain, Sensation, Spasticity, Swallowing, and More After PSE Treatment

Rapid improvement in pain, sensation, spasticity, vision, dysphagia, and taste after PSE Treatment by Danielle Ucci, PA-C, more than 7 years after stroke. Filmed on June 30, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/TwhF8AIE0BQ

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.inrmed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in pain, sensation, spasticity, vision, dysphagia...

09/30/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Post-Stroke Pain, Mobility, & Brain Fog Improved After PSE Treatment at INR

Rapid improvement in pain, mobility, brain fog, and spasticity after PSE Treatment, over 5 years after stroke. Filmed on May 4, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/FhpYNJkFXAA

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.inrmed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in pain, mobility, brain fog, and spasticity afte...

09/23/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Pain & Mobility Improves after PSE Treatment by Dr. Tobinick

Rapid improvement in pain, mobility, spasticity, and brain fog after PSE treatment performed by Dr. Tobinick. Filmed on May 19, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/CkjY12AQlPY

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.inrmed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in pain, mobility, spasticity, and brain fog afte...

09/16/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

PSE Stroke Treatment: Patient Discusses Improvements in Mobility & Balance

Patient discusses improvements in mobility, balance, and more after perispinal etanercept treatment, over seven years after stroke. Filmed on June 16, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/_bcbhgwq8fQ

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.inrmed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Patient discusses improvements in mobility, balance, and more after...

09/09/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery: Improved Sensation, Mobility, & Speech After PSE Treatment by Edward Tobinick, M.D.

Rapid improvement in sensation, mobility, speech, and brain fog after perispinal etanercept treatment by Dr. Tobinick over 1 year after stroke. Filmed on May 12, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/6UJ1hPqOx9g

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.inrmed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in sensation, mobility, speech, and brain fog aft...

09/02/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

PSE Treatment for Stroke Recovery: Improved Pain, Sensation, and Left Neglect

Rapid improvement in pain, sensation, and left neglect after PSE Treatment by Danielle Ucci, PA-C. Filmed on May 21, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/FtFq8swZKIg

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.nrimed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in pain, sensation, and left neglect after PSE Tr...

08/26/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery with Perispinal Etanercept: Rapid Improvement in Mobility & Balance

Rapid improvement in mobility, balance, and spasticity after PSE Treatment by Danielle Ucci, PA-C over 2 years after stroke. Filmed on April 14, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/boANDYG5W1c

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.nrimed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Rapid improvement in mobility, balance, and spasticity after PSE Tr...

08/19/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Post-Stroke Improvements in Pain, Sensation, & Balance after treatment by Edward Tobinick, M.D.

Immediate improvement in pain, sensation, balance, and brain fog after Perispinal Etanercept (PSE) treatment by Dr. Tobinick over 5 years after stroke. Filmed on April 28, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/Not2-l-UBVw

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.nrimed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Immediate improvement in pain, sensation, balance, and brain fog af...

08/12/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery: Sustained & Continued Improvements 1 Year After PSE Treatment

Continuous improvement in mobility, balance, pain, numbness, sensation, and speech after Perispinal Etanercept (PSE) treatment by Danielle Ucci, PA-C after stroke. Filmed April 8, 2025 & April 9, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/5px8VIE4tCc

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.nrimed.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Continuous improvement in mobility, balance, pain, numbness, sensat...

Address

75 Pheasant Run Lane
Buffalo, NY
14086

Opening Hours

Monday	9am - 5pm
Tuesday	9am - 5pm
Wednesday	9am - 5pm
Thursday	9am - 5pm
Friday	9am - 5pm

Website

https://brain-body.org/

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