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Brain-Body Research Institute

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Buffalo, NY
Brain-Body Research Institute

Our mission is to engage in advanced research and education on communication between the nervous and immune systems.

Our ultimate goal is to achieve translation of our research findings into new treatments for neurological disorders. Research Overview
The founding scientific team, pioneers in the field of neuroimmunology, has over the last 30 years made major discoveries in the role of an inflammatory protein in brain functioning. In the clinical setting, they have observed that blocking this protein has profoun

d effects on many pathologies, demonstrating a primary mechanism that can be targeted for treatment of pathologies including:

Neuropathic Pain
Traumatic Brain Injury (TBI)
Stroke
Alzheimer’s
Huntington’s
Cerebral Palsy
Complex regional pain syndrome (CRPS)

In addition to observations in the clinical setting, this scientific team has also published pre-clinical research defining this primary mechanism as a therapeutic target in these additional pathologies:

Diabetic Neuropathy
Concussion
Chronic Pain
Depression

These discoveries in neuroimmunology amount to a paradigm shift in understanding of brain dysfunction. The public will only benefit from these discoveries when they are translated into effective treatments and prevention methods for the above dysfunctions. This is what we are committed to achieve at the Brain-Body Research Institute.

05/27/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Post-Stroke Fatigue & Speech Improvement with PSE Treatment at Institute of Neurological Recovery

Daughter discusses mother's improvement in stamina, energy, and speech after PSE treatment, performed by Danielle Ucci, PA-C. Filmed on February 26 & March 2, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/bf8id72NDls

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Daughter discusses mother's improvement in stamina, energy, and speech after PSE treatment, performed by Danielle Ucci, PA-C. Filmed on February 26 & March 2...

05/20/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Post-Stroke Spasticity & Sensation Improved after PSE Treatment by Dr. Tobinick, 3 Years Post-Stroke

Rapid improvement in post-stroke spasticity, sensation, and speech after PSE treatment by Dr. Tobinick, 3 years after stroke. Filmed on February 17, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/GCma43_eF2c

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

3 likes. "Post-Stroke Spasticity & Sensation Improved after PSE Treatment by Dr. Tobinick, 3 Years Post-Stroke"

05/13/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery: Walking Without Cane after PSE Treatment by Edward Tobinick, M.D.

Immediate improvement in post-stroke pain, walking, and hand function after PSE treatment by Dr. Tobinick, 2.5 years after stroke. Filmed on January 13, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/IMiXy3ikM0c

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery: http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about-the-institute/terms-of-use/

Immediate improvement in post-stroke pain, walking, and hand function after PSE treatment by Dr. Tobinick, 2.5 years after stroke. Filmed on January 13, 2026...

05/06/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Continuous Improvement in Stroke Recovery with PSE Treatment: "It's Life-Changing"

Sustained & continuous improvement in post-stroke pain, mobility, hand function, cognition, swallowing, and fatigue after PSE Treatment by Dr. Tobinick, since 2 strokes in 2023. Filmed on January 22, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/GMreFb4oawM

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

Sustained & continuous improvement in post-stroke pain, mobility, hand function, cognition, swallowing, and fatigue after PSE Treatment by Dr. Tobinick, sinc...

04/29/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Rapid Post-Stroke Shoulder Pain Relief with PSE Treatment, 2.5 Years After Stroke

Rapid improvement seen after PSE treatment, including: post-stroke shoulder pain reduction (7/10 pain before treatment → 3/10 pain after treatment), improved spasticity, numbness, vision, and fatigue. Filmed on January 21, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/Mlx-uOg5aHE

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

32 likes, 1 comment. "Rapid Post-Stroke Shoulder Pain Relief with PSE Treatment, 2.5 Years After Stroke"

04/22/2026

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Post-Stroke Progress: Spasticity, Mobility, and Fatigue Improved with PSE Treatment

Improvements in spasticity, mobility, fatigue, and swallowing after PSE treatment, 6 months after stroke. Filmed on January 14, 2026 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Watch Here: https://youtu.be/pgIZmxOBcjc

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

55 likes, 2 comments. "Post-Stroke Progress: Spasticity, Mobility, and Fatigue Improved with PSE Treatment"

04/15/2026

https://youtu.be/fkZt6hhq-Jc

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery: Patient from Zimbabwe Rapidly Improves with PSE Treatment by Dr. Tobinick

Patient from Zimbabwe sees rapid improvement in post-stroke pain, speech, brain fog, sensation, and taste after PSE treatment by Dr. Tobinick, 2 years after stroke. Filmed on December 9 & December 16, 2025 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

Patient from Zimbabwe sees rapid improvement in post-stroke pain, speech, brain fog, sensation, and taste after PSE treatment by Dr. Tobinick, 2 years after ...

04/08/2026

https://youtu.be/0ZLGSyXYvoM

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Singer Lucinda Williams' Stroke Recovery Advances with Perispinal Etanercept by Dr. Edward Tobinick

Grammy-winning singer-songwriter, Lucinda Williams, shows immediate improvement in left-sided neglect, brain fog, walking, balance, and more after perispinal etanercept treatment by Dr. Edward Tobinick, 6 years after stroke. Filmed on December 22 & December 29, 2025 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

Grammy-winning singer-songwriter, Lucinda Williams, shows immediate improvement in left-sided neglect, brain fog, walking, balance, and more after perispinal...

04/01/2026

https://youtu.be/3Mx6CohzoSo

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Post-Stroke Spasticity & Walking Improved After PSE Treatment at INR

Rapid improvement in spasticity, walking, sensation, allodynia, and taste after PSE treatment performed by Danielle Ucci, PA-C, 1 year after stroke. Filmed on November 12, 2025 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

Rapid improvement in spasticity, walking, sensation, allodynia, and taste after PSE treatment performed by Danielle Ucci, PA-C, 1 year after stroke. Filmed o...

03/25/2026

https://youtu.be/eb-xNoHr61Q

Dr. Robert Spengler, Dr. Tracey Ignatowski, and Dr. Edward Tobinick

This pioneering treatment, rooted in the groundbreaking work by Dr. Robert Spengler and Dr. Tracey Ignatowski, furthered by the work of Dr. Edward Tobinick in perispinal administration of etanercept, underscores the value and importance of this research relating to TNF and the work done at the Brain-Body Research Institute.

Stroke Recovery: Improved Mobility & Sensation after PSE Treatment by Edward Tobinick, M.D.

Immediate improvement in mobility, sensation, balance, vision, and taste after PSE treatment by Dr. Tobinick, 10 months after stroke. Filmed on December 4, 2025 at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

Additional Information:
Drugs. com: Perispinal Etanercept for Stroke Recovery - 2023 REVIEW http://bit.ly/3KvFJPe
Florida Doctor Gives Stroke Patients a New Shot at Mobility, Independence: https://bit.ly/3phc56k
Edward Tobinick, M.D. Information: https://bit.ly/36JE4Fx
Edward Tobinick, M.D. Google Scholar: https://bit.ly/3heyKvT
On Overcoming Barriers to Neuroinflammation Research (Tobinick, et al): https://bit.ly/3tcxIGf

LEARN MORE: https://www.strokebreakthrough.com/
REQUEST A CONSULTATION TODAY: https://bit.ly/3Hn6v8X
SEE MORE STROKE VIDEOS: https://bit.ly/36BqvYx
YOUTUBE CHANNEL: https://bit.ly/3M5HbYk
CALL: +1 (561) 353-9707

Text, images and video © 2026, INR PLLC, all rights reserved. Disclaimer: Individual results vary, not all patients respond. This treatment is a patented invention of the INR PLLC. Please see https://www.strokebreakthrough.com/about.../terms-of-use/

Immediate improvement in mobility, sensation, balance, vision, and taste after PSE treatment by Dr. Tobinick, 10 months after stroke. Filmed on December 4, 2...

Address

75 Pheasant Run Lane
Buffalo, NY
14086

Opening Hours

Monday	9am - 5pm
Tuesday	9am - 5pm
Wednesday	9am - 5pm
Thursday	9am - 5pm
Friday	9am - 5pm

Website

https://brain-body.org/

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