National Network of Depression Centers

National Network of Depression Centers A collaborative network of mental health researchers focusing on depression and bipolar disorder.

The National Network of Depression Centers is a 501(c)(3) non-profit research consortium dedicated to advancing scientific knowledge, improving care, and driving the national conversation on depression and related mood disorders. With more than 600 members from 25 leading academic institutions across the country, the NNDC has a unique capacity for effecting meaningful change through large-scale collaborative efforts. NNDC Members work together on Task Groups to tackle issues faced by specific populations or develop treatment guidelines for specific diagnoses; design and implement innovative clinical trials using cutting-edge treatments and technologies; and advocate for positive change in mental health policy on both state and national levels.

10/11/2026

That’s a wrap for the 2026 Best Practices for Mood Disorders in collaboration with Mayo Clinic, supported by University of Colorado Anschutz! We thoroughly enjoyed Denver and connected over some of the best clinical pearls in mood disorder education. We are grateful for all those who joined us this weekend, our sponsors who supported this effort, and a special thank you to our friends at CU Anschutz, who were wonderful hosts for our first year in Colorado. We’ll share more updates from the conference in the coming days, but wanted to share a few highlights and our gratitude for everyone who was a part of the conference now!

Today, October 10th 2026 is World Mental Health Day. Explore global and local events honoring World Mental health Day. F...
10/10/2026

Today, October 10th 2026 is World Mental Health Day.

Explore global and local events honoring World Mental health Day. From expert-led panel discussions to community workshops, find meaningful opportunities to connect, learn, and advocate for mental health awareness worldwide.

Link: https://wmhdofficial.com/events/

2026 NNDC Annual Conference Gold Sponsor Spotlight: Otsuka America Pharmaceutical, Inc. and Otsuka Pharmaceutical Develo...
10/10/2026

2026 NNDC Annual Conference Gold Sponsor Spotlight: Otsuka America Pharmaceutical, Inc. and Otsuka Pharmaceutical Development & Commercialization, Inc.

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Otsuka America Pharmaceutical, Inc. and Otsuka Pharmaceutical Development & Commercialization, Inc. are the US-based indirect subsidiaries of the global healthcare company Otsuka Pharmaceutical Co. Ltd. Otsuka’s US companies share a deep commitment to the development and commercialization of innovative products in the spaces of neuroscience, nephrology, and immunology.

At Otsuka, we hold a deep respect for the value of every mind. We will not rest until mental illnesses and brain diseases are approached with the same priority and urgency as our physical health and recognized as chronic diseases that warrant early, equitable, and accessible intervention for patients and caregivers everywhere.

Annual Conference Details: https://nndc.org/nndc-annual-conference/

“Mayo Clinic had the opportunity to partner with the NNDC as a participating site in the multi-site Bio-K trial. This t...
10/08/2026

“Mayo Clinic had the opportunity to partner with the NNDC as a participating site in the multi-site Bio-K trial. This trial recruited patients suffering with treatment-resistant depression to receive open-label ketamine. While receiving infusions, participants donated blood samples, giving researchers across the NNDC an opportunity to investigate biomarkers that might one day help us better understand and predict treatment response and remission.

However, this trial provided so much more than what can be fully captured in data or seen on paper. Many of the patients who participated had lived for years with debilitating symptoms of depression. Their lives, and the lives of the people who loved them, had been profoundly disrupted by an illness that had not responded adequately to previous treatments. They came to us willing to participate in research, hopeful that it might offer answers not only for themselves but for others living with depression.

Unlike other traditional treatments offered in psychiatry, ketamine can provide a rapid improvement in symptoms, often within a matter of hours to days. As one of the physicians involved in the study, I had the privilege of witnessing those changes firsthand. I remember a participant who arrived visibly burdened by her depression. Just 24 hours after her first infusion, her well-being had shifted entirely. Her affect was brighter. Her speech was faster. Her motor movements were more fluid. Her spouse told us it was the best he had seen her in many years.

Another participant had become so limited by his depression that he was largely confined to his home and unable to participate in family life. As his symptoms improved, he began attending his children’s soccer games again. He could take part in activities with his family. His partner came to us in tears and told us, “This is the person I married.” Time after time, patients have highlighted how this treatment had been life-changing and life-saving, not only for them, but their families as well.

The impact of the Bio-K trial extended well beyond the individual patients who participated. At the time, ketamine infusions for treatment-resistant depression were still considered relatively novel in the field. Through our collaboration with the NNDC, our multidisciplinary team gained invaluable experience providing this emerging treatment in the carefully structured environment of a clinical trial. We learned what to monitor, how to educate and prepare our staff, and how to build processes that could ultimately translate from a research protocol to a clinical ketamine service. That experience helped lay the groundwork for a robust clinical practice at Mayo Clinic, allowing us to offer this treatment to many more patients with treatment-resistant depression. For me, seeing patients and families thrive when they were unable to do so before is among the greatest privileges of my career.”

— Jennifer Vande Voort, MD
Mayo Clinic

Learn more and donate here: https://nndc.org/campaign/

About: BIO-K (Biomarkers of Ketamine) was a multicenter, open-label clinical study designed to investigate how IV ketamine works in treatment-resistant depression (TRD) and, importantly, whether biological markers could help predict who responds to treatment. The study included Mayo Clinic, University of Michigan, Johns Hopkins Medicine, and Pine Rest, and while the trial is now closed, the findings continue to inform current practices in ketamine treatment for depression.

The launch of People Behind the Progress, final conference reminders, member news, what we're following and more! Catch ...
09/29/2026

The launch of People Behind the Progress, final conference reminders, member news, what we're following and more!

Catch it all in the September newsletter here:
https://conta.cc/3VGdpmh

Johnson & Johnson is a global healthcare leader, committed to solving the toughest health challenges and transforming li...
09/29/2026

Johnson & Johnson is a global healthcare leader, committed to solving the toughest health challenges and transforming lives through research, development, manufacture and distribution of innovative medicines and medical technologies.

The company’s Innovative Medicine business advances breakthrough science and develops transformational treatments in areas like oncology, immunology, neuroscience, and cardiopulmonary. In MedTech, the company is focused on developing and delivering cardiovascular, surgery, and vision solutions.

Visit jnj.com to learn more.

Gold Sponsor Spotlight for the 2026 NNDC Annual Conference | October 19 - 21 | Austin, TexasSupernus Pharmaceuticals and...
09/28/2026

Gold Sponsor Spotlight for the 2026 NNDC Annual Conference | October 19 - 21 | Austin, Texas

Supernus Pharmaceuticals and Biogen have partnered together to bring a treatment option to people experiencing postpartum depression. By combining expertise in brain health and biotechnology, we’re working with the healthcare community to help improve awareness and education of postpartum depression.

“I'm so thankful to the NNDC for the incredible opportunity to attend the Best Practices Conference. The experience was ...
09/28/2026

“I'm so thankful to the NNDC for the incredible opportunity to attend the Best Practices Conference. The experience was truly invaluable, and I’m so grateful for the scholarship support that made it possible for me to attend. Without that financial assistance, I would not have been able to participate, and I’m deeply appreciative of the chance to learn from experts and peers in the field.

Since returning, I’ve already been able to apply what I learned to my primary care clerkship, where I primarily work with the HIV-positive population in Austin. The knowledge I gained about mood disorders and patient communication has made me more thoughtful and effective in how I interact with my patients. I’ve found that I’m better able to recognize when mood symptoms may be affecting overall health and to approach those conversations with greater empathy and confidence.

The conference not only strengthened my clinical skills but also deepened my commitment to continuing to grow as a provider who understands the complex relationship between mental and physical health. I left feeling inspired and better prepared to support my patients in a more holistic way.

Thank you again for your generosity and for making this experience possible. I’m truly grateful for the opportunity and for the lasting impact it has had on my medical training and professional development.“

—Aidan Smith, Best Practices for Mood Disorders Travel Award Recipient and MD Candidate with Dell Medical School - UT Austin

Learn more and donate here: https://nndc.org/campaign/

As champions of innovation, we know that every breakthrough begins with a person.A researcher asking a new question. A c...
09/28/2026

As champions of innovation, we know that every breakthrough begins with a person.

A researcher asking a new question. A clinician finding a better way to help a patient. A family member sharing hope. An advocate turning lived experience into action. A colleague reaching across institutions to solve a problem together.

These are the People Behind the Progress.

Today, we’re launching NNDC’s year-end giving campaign, People Behind the Progress: Stories of Innovation, Care and Hope — celebrating the people and ideas moving depression and bipolar disorder research, treatment and care forward.

Over the coming weeks, we’ll share stories from across the NNDC Network — highlighting innovative research, meaningful collaborations, advances in clinical care, treatment successes, problem-solving and, most importantly, the people who make this work possible.

A new story will be featured each week through the end of the year.

And we want to hear from you.

If you’re an NNDC member, faculty member, researcher, clinician, advocate, patient, family member or partner, tell us about the work you’re proud of.

What are you researching?
What problem are you working to solve?
Who have you collaborated with?
What progress have you seen?
What gives you hope for the future?

Your story may inspire someone else — and together, these stories show the extraordinary impact of this Network.

Support the Work Behind the Stories
Our goal this year is to help NNDC continue bringing people and institutions together to advance research, improve care, share knowledge and create meaningful progress for people living with depression and bipolar disorders.

Whether you give $25, $100, $500 or more, your support is an investment in the people behind the progress — and in what we can accomplish together.

👉 Make a donation: https://nndc.org/campaign/

And please share this campaign with your colleagues, faculty, friends and networks. If NNDC has made a difference in your work, your research, your care or your understanding of mood disorders, help us tell that story.

Because progress doesn’t happen alone.

It happens when people come together, share what they know, challenge what’s possible and believe there is a better way forward.

Thank you for being one of the People Behind the Progress.

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