Persona Foundation

28/02/2026

To dla nas ogromne wsparcie i wyróżnienie!
Dziękujemy! 🩷

27/02/2026

Zachęcamy do rozliczenia 1,5% podatku na badania, które realizujemy 🩵

18/02/2026

17/02/2026

PL 🇵🇱 | Badania na nicieniach w IBB PAN! 🔬🪱
W walce o lek korzystamy z najlepszych narzędzi. Nasz projekt na nicieniach (C. elegans) postępuje.
📍 Co robimy? Obecnie testujemy leki na standardowym modelu mutanta L1CAM, pozyskanym z profesjonalnego banku genetycznego.
🔍 Nasz cel: Szukamy cząsteczek, które cofną skutki mutacji i poprawią sprawność organizmu.
🚀 Co dalej? Równolegle powstaje spersonalizowany model z dokładną mutacją (c.2254G>A), na którym sprawdzimy najlepsze trafienia.

EN 🇬🇧 | Nematode research at IBB PAS! 🔬🪱
We are using world-class tools to find a cure for L1 Syndrome. Our C. elegans project is moving forward.
📍 Current phase: We are screening drugs using a standardized L1CAM mutant model from a global genetic stock center.
🔍 The goal: We are searching for molecules that reverse the effects of the mutation and improve functional outcomes.
🚀 Next step: A personalized model with specific mutation (c.2254G>A) is being developed to validate our top findings.

27/11/2025

🇵🇱🧬 L1CAM: Odkrywamy Nowe Życie dla Niefunkcjonalnego Białka! 🧬

Nasz cel? Przywrócić funkcjonalność kluczowego białka L1CAM w rozwiniętym układzie nerwowym.

Co robimy?
• Problem: Mutacje (np. c.2254G>A) sprawiają, że białko L1CAM jest pełnej długości, ale niefunkcjonalne (L1-LF). Musimy je 'ożywić'!
• Rozwiązanie: Stosujemy Drug Repurposing – szukamy nowych zastosowań dla leków już zatwierdzonych i bezpiecznych. To przyspiesza drogę do terapii!
• Nasze Narzędzia: Prowadzimy screening na nicieniach i liniach iPSC od pacjentów.
• Przyszłość: Wykorzystujemy AI do identyfikacji najbardziej obiecujących kandydatów.



🇬🇧🧬 L1CAM: Unlocking New Life for a Non-Functional Protein! 🧬

Our goal? To restore the functionality of the crucial L1CAM protein in an already developed nervous system.

What are we doing?
• The Problem: Mutations (e.g., c.2254G>A) result in a full-length L1CAM protein that is non-functional (L1-LF). We need to 'revive' it!
• The Solution: We're using Drug Repurposing – finding new uses for drugs already approved and safe. This accelerates the path to therapy!
• Our Tools: We conduct screening on nematodes and patient-derived iPSC lines.
• The Future: We leverage AI to identify the most promising candidates.

14/10/2025

PL / Warto zajrzeć na profil Agencja Badań Medycznych. Bardzo cenna inicjatywa edukacyjna pokazująca jak powstaje lek. Jest to też droga, którą my jako fundacja wytrwale podążamy 👩‍🔬 🔦💊

ENG / It’s worth checking out the profile of the Medical Research Agency. A very valuable educational initiative showing how a medicine is developed. It’s also the path that we, as a foundation, are diligently following 👩‍🔬🔦💊

10/06/2025

🇬🇧 📍Barcelona | REMEDi4ALL Bootcamp

We had the honor of participating in a unique training dedicated to the role of patients in the drug repurposing process 💊💬

Over 30 patient organizations from across Europe, intensive workshops, inspiring conversations, and… a board game about medicines! 🎲

Thank you for the knowledge, support, and the opportunity to help shape the future of medicine 💙

What we are taking away from this week?
🧠 Solid knowledge
🤝 New connections
💡 Practical ideas for future projects
❤️ And even stronger motivation to keep going

🇵🇱 📍Barcelona | REMEDi4ALL Bootcamp

Mieliśmy zaszczyt wziąć udział w wyjątkowym szkoleniu dla przedstawicieli pacjentów, poświęconym roli pacjentów w procesie repozycjonowania leków 💊💬

Ponad 30 organizacji pacjenckich z całej Europy, intensywne warsztaty, inspirujące rozmowy i… gra planszowa o lekach! 🎲

Dziękujemy za wiedzę, wsparcie i możliwość współtworzenia przyszłości medycyny 💙

Co zabieram ze sobą po tym tygodniu?
🧠 Konkretną wiedzę
🤝 Cenne kontakty
💡 Nowe pomysły na działania fundacji
❤️ I jeszcze większą motywację

16/05/2025

The Institute of Biochemistry and Biophysics, Polish Academy of Sciences, is announcing a PhD position within the project:

🧪 Title: “Modeling L1CAM Syndrome in the Nematode C. elegans”
💡 Supervisor: Prof. Róża Kucharczyk (team with Dr. Krzysztof Drabikowski)
🎓 Who can apply? Graduates in biochemistry, molecular biology, genetics, or related fields, with at least one year of research experience (experience with C. elegans is a plus)

🔬 Project goal: To create C. elegans models of L1CAM mutations related to a rare neurological disease and test FDA-approved drugs for potential repurposing.

A great opportunity for those passionate about gene therapy and rare disease research!

Join Us – You Might Be the One!

15/02/2025

📸 Family, love, and strength – together against L1CAM! 💙

Today, we want to share some special moments of our amazing kids and their families. Each photo tells a story of love, challenges, and incredible strength.

At the Persona Foundation, we are building a community where no one is alone.

💙 We are also working with scientists to advance research that could help our boys in the future. Every step brings us closer to hope!

If you want to help – like, share, or join us! Together, we can do more!

04/02/2025

Did you ever wonder how the L1 protein looks like? 🤔

Thanks to AlphaFold it is now possible! 👏

How Is it Transforming Genetics and Medicine?

1. A Better Understanding of Genetic Diseases 🧬

Many genetic disorders result from mutations that alter protein structures. Now, scientists can:

• Identify how mutations affect protein shape and function,

• Understand why specific changes lead to diseases,

• Develop strategies to correct defective proteins.

2. Accelerating Drug Discovery 💊

Traditional methods for determining protein structures, such as X-ray crystallography or NMR spectroscopy, are time-consuming and expensive. AlphaFold enables:

• Rapid prediction of protein structures,

• Identification of potential drug targets,

• The design of more precise therapies based on molecular-level drug engineering.

3. Targeted Therapies and Personalized Medicine 🎯

With AlphaFold, researchers can:

• Develop treatments tailored to individual mutations,

• Test potential drugs on protein models instead of in the lab,

• Create gene therapies that restore proper protein function.

How it might help with L1 Syndrome?

In L1 Syndrome, mutations in the L1CAM protein lead to neurological disorders. Now it possible to:

✅ Accurately model the structure of both healthy and mutated L1CAM,

✅ Identify potential drugs that could restore its function,

✅ Develop gene therapies that correct faulty sequences.

Future is now:

🔹 New treatments for genetic diseases,

🔹 Faster and more affordable drug discovery,

🔹 The potential to cure previously untreatable conditions.

Thanks to AI, medicine and genetics are entering a new era! 🚀

14/11/2024

We present the masterminds behind all the action Persona Foundation is a family foundation Anna Grata-Grzegorz Grata👫+👦

07/11/2024

It will be loud about L1CAM ☺️