HIV/AIDS cure news

07/11/2025

Really Good news https://www.facebook.com/share/p/17Pihf9g3H/

Researchers at the University of Cologne have identified an antibody, 04_A06, that neutralized about 98.5% of over 300 HIV-1 strains. In humanized mice, it reduced the virus to undetectable levels by targeting the CD4 binding site, a weak spot shared across HIV variants. The finding marks a major step toward universal HIV prevention and treatment.

15/07/2025

https://www.facebook.com/share/p/1FSJ1uhS9A/

Researchers have developed a groundbreaking way to make HIV visible inside the white blood cells where it hides, potentially paving the way to fully clear the virus from the body. HIV’s ability to remain dormant inside these cells has been a major obstacle in curing the infection because current treatments can’t eliminate this hidden reservoir.

Using mRNA technology similar to that in Covid-19 vaccines, the team created a new type of fat-based nanoparticle, called LNP X, that can deliver mRNA into the specific white blood cells housing HIV. This mRNA instructs the cells to reveal the hidden virus. Earlier attempts to deliver mRNA to these cells failed because they wouldn’t absorb the particles, but this new design overcomes that barrier.

In laboratory tests using cells from HIV patients, the researchers were amazed at how effectively the virus was exposed, calling the results “night and day” compared to previous efforts. While this breakthrough doesn’t yet clear the virus, it offers a promising step toward new treatments that could combine this technology with other therapies to eliminate HIV completely.

18/03/2025

Pioneering trials discover potential strategy to keep virus in check after stopping treatment

03/03/2025

A functional cure for HIV refers to a state where patients can cease ART. The main research directions include gene therapy and immunotherapy. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1540932/full #:~:text=A%20functional%20cure%20for%20HIV%20refers%20to%20a%20state%20where,include%20gene%20therapy%20and%20immunotherapy.

03/03/2025

These findings highlight the ability of CRISPR/Cas9 to target both integrated proviral DNA and non-integrated viral genomes in latently infected cells,

Recent advances in virology, particularly in the study of HIV-1, have significantly progressed the pursuit of a definitive cure for the disease. Emerging therapeutic strategies encompass innovative gene-editing technologies, immune-modulatory interventions, and next-generation antiretroviral agents....

03/03/2025

https://www.gilead.com/company/company-statements/2024/gilead-submits-new-drug-application-to-us-food-and-drug-administration-for-twice-yearly-lenacapavir-for-hiv-prevention #:~:text=In%20addition%2C%20the%20FDA%20granted,of%20a%20drug%20application%20by

Foster City, Calif., December 19, 2024 – Gilead Sciences, Inc. (Nasdaq: GILD) today announced the company completed New Drug Application (NDA) submissions to the U.S. Food and Drug Administration (FDA) seeking approval of an investigational use of lenacapavir—the company’s twice-yearly injecta...

03/03/2025

https://aidsfonds.org/news-stories/six-groundbreaking-hiv-cure-studies-funded/

Get the latest updates on HIV cure research. Learn about the innovative proposals that Aidsfonds and Sidaction are funding.