21/09/2026
This World Alzheimer's Day, we're highlighting research that shows how discoveries in one field can help advance understanding in another.
At the University of Southampton, PhD researcher Charlie Ellis, supervised by Dr Arjuna Ratnayaka, is investigating lysosomes, the tiny structures inside our cells responsible for breaking down and recycling waste.
Previous studies have shown that lysosomal dysfunction plays an important role in age-related macular degeneration (AMD), a leading cause of sight loss, but similar cellular processes are also implicated in conditions such as Alzheimer's and Parkinson's disease.
By understanding how these cellular "recycling systems" become damaged with age, our vision scientists are helping to uncover new insights that could have implications across multiple areas of health research.
We're delighted that, thanks to the generosity of a legacy supporter, Charlie will continue this important work at Southampton as a postdoctoral researcher from November.
Over the next two years, he will build on discoveries made during his PhD while helping to advance our understanding of both sight loss and wider age-related disease.
This study demonstrates how eye research has the potential to unlock insights into diseases beyond those affecting vision alone.
Health Research Southampton