17/06/2026
From significantly poor survival to a highly manageable condition, the story of chronic myeloid leukaemia (CML) remains one of haematology's greatest success stories. ๐ฉธ
Just 25 years ago, patients with CML faced limited treatment options.
Allogeneic stem cell transplantation was the only potentially curative therapy, but it carried significant risks and long-term complications. Before the era of Imatinib, 5-year survival rates were often below 50%.
The introduction of Imatinib - the first targeted tyrosine kinase inhibitor (TKI), a drug designed to block the abnormal BCR::ABL protein that drives CML - transformed outcomes for patients worldwide.
Today, 5-year survival approaches 90%, and many patients can expect near-normal life expectancy.
This breakthrough paved the way for multiple generations of TKIs, further improving efficacy, tolerability, and treatment options for people living with CML.
This May, the haematology community celebrated the remarkable "molecule" that changed the course of CML treatment forever. More than a scientific achievement, it is a discovery that has transformed and continues to transform the lives of countless patients and families around the world. ๐