European Thyroid Journal

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The European Thyroid Journal publishes papers reporting original research in basic, translational and clinical thyroidology.

The official journal of the European Thyroid Association, publishing basic, translational and clinical thyroidology. 2025 Journal Impact Factor: 4.9/2025 CiteScore: 7.2 Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.

08/10/2026

A new report describes a calcitonin-negative medullary thyroid carcinoma (MTC)-like thyroid tumour that was subsequently reclassified as primary thyroid paraganglioma (TPGL) following review by a specialist endocrine pathologist. A three-generation family history subsequently identified carotid body paragangliomas in the father and brother of the patient, with germline testing identifying a heterozygous intronic SDHD variant (NM_003002.4:c.314+4A>G) in all three affected relatives. Peripheral blood RNA sequencing demonstrated activation of a cryptic donor site 4 bp downstream of exon 3, supporting a splice-disrupting effect.

This case report illustrates two practical safeguards in the evaluation of an unusual thyroid tumour: obtaining a comprehensive family history early in the diagnostic process and timely review by a pathologist experienced in endocrine and neuroendocrine tumours.

Read the case report: https://doi.org/10.1530/ETJ-26-0226

06/10/2026

A new study prospectively evaluates changes in HPG axis parameters in adult men treated for thyroid dysfunction (primary hyperthyroidism and hypothyroidism), with a specific focus on alterations in s*x hormone-binding globulin (SHBG), testosterone, estradiol, and their ratio.

Read the study: https://doi.org/10.1530/ETJ-26-0111

01/10/2026

Can follow-up be safely de-escalated for patients with low-risk differentiated thyroid carcinoma (DTC) who achieve an excellent response to initial treatment?

A new multicentre retrospective study found no recurrences among 379 low-risk DTC patients, with an excellent response to initial treatment, during a median follow-up of 6.7 years.

The incidence of indeterminate response was 11.8 events per 1,000 person-years, peaking around year 3 after surgery and declining to near zero after year 7. Using the 2025 ATA response-to-therapy criteria, 95.8% of patients maintained an excellent response at last follow-up, and no variables were significantly associated with the development of an indeterminate response.

Read the study: https://doi.org/10.1530/ETJ-26-0223

29/09/2026

A new study found an association between maternal thyroid disease and venous thromboembolism (VTE) diagnosed in relation to pregnancy in a large, nationwide cohort.

The study utilised nationwide health registers in Denmark to perform an observational cohort study of pregnancies exposed to maternal hyperthyroidism or hypothyroidism. Cases of VTE during pregnancy and up to one year after pregnancy were identified, and multivariate logistic regression was used to evaluate the association between maternal thyroid disease and venous thromboses.

Read the full study: https://doi.org/10.1530/ETJ-26-0154

24/09/2026

A new review by Linh T T Nguyen et al. summarises mechanisms of telomerase reverse transcriptase (TERT) activation in thyroid cancer, the biological consequences of promoter mutations, clinical utility as biomarkers, and emerging therapeutic strategies, including the most recent advances made in the field in the recent years.

Read the review: https://doi.org/10.1530/ETJ-26-0068

This paper forms part of the Novel Insights in Advanced Thyroid Carcinoma: From Mechanisms to Treatments Special Collection, edited by Efisio Puxeddu, Iwao Sugitani and Iñigo Landa

22/09/2026

A new review by Michaela Kuhlen et al. summarizes current evidence and practical management considerations for thyroid nodules in children and adolescents with cancer predisposition syndromes (CPSs), with a focus on follicular cell-derived nodules and non-medullary thyroid carcinoma (NMTC).

The review proposes a CPS-adapted, multidisciplinary risk-assessment framework to support evaluation and management and highlights the need for prospective multicentre registries and harmonized protocols to define syndrome-specific outcomes and evidence-based thresholds for surveillance and intervention.

Read the review: doi.org/10.1530/ETJ-26-0100

17/09/2026

Does progesterone luteal phase support (LPS) affect thyroid function?

New research investigates whether LPS with natural progesterone affects thyroid function in modified natural frozen embryo transfer (FET) cycles, as assessed by TSH and fT4.

Read the research: https://doi.org/10.1530/ETJ-26-0099

15/09/2026

New research investigates the dependence of murine thyroid cancer cell lines on COPZ1, a subunit of coatomer complex I, and the molecular mechanisms involved.

The study demonstrates that inflammatory responses following COPZ1 silencing are cell line-dependent. COPZ1 silencing impaired cell proliferation and induced ER stress in four cell lines, activated a transcriptional and secretory IFN-I-related program in two cell lines, and increased ROS production, lipid peroxidation, and Ca²⁺ levels in the other two cell lines.

Read the research: https://doi.org/10.1530/ETJ-25-0408

10/09/2026

What is the clinical value of intraoperative high-frequency ultrasound in assessing the capsular continuity of thyroid follicular neoplasms?

A new study explores the feasibility of using intraoperative high-frequency ultrasound to identify tumor capsular abnormalities and guide optimized sampling for intraoperative frozen section analysis, with the goal of improving sensitivity and accuracy in differentiating thyroid follicular neoplasms.

The study demonstrates that intraoperative high-frequency ultrasonography can effectively identify abnormalities in tumor capsular continuity, guide optimized sampling for intraoperative frozen section analysis, significantly improve the intraoperative detection of malignant tumors, and provide reliable intraoperative guidance.

Read the research: https://doi.org/10.1530/ETJ-26-0040

03/09/2026

✈️ See you in Porto!

The European Thyroid Journal will be attending the 47th Annual Meeting of the European Thyroid Association on 5-8 September.

If you're thinking about your next publication, stop by for a chat and learn more about publishing with the official journal of the European Thyroid Association.

We look forward to meeting you and hearing about your latest research.

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https://etj.bioscientifica.com/

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