09/02/2026
Membrane potential is the difference in voltage between the inside and outside of a membrane (e.g., cell membrane, mitochondrial membrane). It’s created by concentration gradients of ions (molecules that have an electrical charge), and it powers a cell's essential functions, like producing energy and sending signals.
In ME/CFS, there is evidence that cells and mitochondria in patients may struggle to maintain this electrical balance. This can disrupt the body's ability to generate energy and may help explain the profound fatigue that people experience.
OMF’s Collaborative Center at Stanford University is investigating decreased mitochondrial membrane potential through the itaconate shunt hypothesis. Read more about the study on our website: https://ow.ly/a65b50ZHsAe.