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OMF Canada is working to create a world where people with chronic diseases like myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) live full, productive lives.

10/15/2026

OMF Founder & CEO Linda Tannenbaum recently visited OMF’s ME/CFS Collaborative Research Center at Montreal, where each team member shared a presentation of their ongoing work.

The passion in that room was clear. “They are excited about their own research,” Linda said.
This kind of direct connection between OMF leadership and our researchers reflects the collaborative approach to systems research that drives discovery. We’re grateful to the team for their warm welcome and their dedication to the people counting on this work.

10/14/2026

🧬 Science Wednesdays: What is a mechanism of action?

A treatment's mechanism of action is the specific biological process by which it produces its effect in the body.

Understanding mechanism of action helps clinicians make smarter, more personalized treatment choices for people living with ME/CFS, Long COVID, and other multi-system chronic complex diseases.

OMF's Collaborative Center at Montreal is trialing treatments that target specific biological differences found in based on what we already know of a drug’s mechanism of action.

🔗 Read more about this project: https://ow.ly/Htqa50ZXoVq

10/09/2026

Why do people with Long COVID and ME/CFS wake up unrefreshed, even when a standard sleep study looks close to normal? A 2026 study in the journal SLEEP points to the fine-grained structure of sleep itself.

In this OMF Journal Club, Dr. Danielle Meadows walks through "Facility-Measured Sleep Electroencephalographic Microstructures in Long COVID" (Sun et al., 2026), a paper from Dr. Janet Mullington's team in collaboration with OMF's Computational Research Center for Complex Diseases.

👉 Learn more about this publication: https://ow.ly/46FV50ZWix6
👉 Watch Journal Club recording: https://ow.ly/RzoE50ZWix7

10/08/2026

Today is DAF Day, a day dedicated to the power of Donor-Advised Funds (DAFs) to make a difference.

A grant from your DAF to OMF Canada can:
👉 Fund research that federal agencies chronically underinvest in
👉 Support a collaborative model that multiplies each dollar across OMF's global research network
👉 Accelerate the path to diagnostics and treatments
👉 Advance science that will reshape how medicine understands multisystem chronic complex diseases

Recommend your grant for DAF Day: https://www.omfcanada.ngo/ways-to-donate/

10/07/2026

Multi-omics is a style of research that combines multiple layers of biological data—including genomics (genes), proteomics (proteins), and metabolomics (metabolites)---to build a complete picture of what is happening inside the body. Instead of studying one biological system at a time, multi-omics looks at many systems simultaneously to identify patterns.

As a multi-system chronic complex disease, multi-omics is incredibly valuable in ME/CFS research. A single-focus study often misses the bigger picture in multi-system diseases, so multi-omics better helps researchers connect the dots across biology, moving us closer to understanding the root causes of .

OMF’s Collaborative Center at Montreal is using this in their Multi-Omic Approaches to Solve Post-Acute COVID-19 (MOSAIC) project, which is trying to facilitate early detection of ME/CFS in people with and better understand disease progression.

🔗Read more about the study: https://ow.ly/ewqc50ZVtEQ

09/30/2026

Systemic is a term that describes something that affects the whole body—its systems, organs, and processes all at once—rather than just one isolated area. Systematic refers to a methodical, step-by-step approach to doing something. In the context of medical research, a disease can be systemic, while the research investigating it should be systematic.

ME/CFS is a systemic disease—it disrupts the immune system, nervous system, energy production, and more, all at the same time. Therefore, systematic research into the disease that addresses the impact on the whole body is critical.

OMF takes a systematic research approach, using rigorous, coordinated methods across multiple scientific disciplines to capture the full picture of how ME/CFS works—acknowledging and addressing the systemic nature of the disease.

🔗 Read more about OMF’s research portfolio: https://ow.ly/kOIv50ZS12H

09/29/2026

The 2026 Stanford Community Symposium recordings are now on YouTube.

On September 11, Dr. Ronald W. Davis and the Stanford team opened the final day of the Stanford Working Group Meeting to the community.

People living with and , caregivers, clinicians, and others with a stake in this science joined virtually to hear directly from the researchers.

Every talk is now online, including Danielle Meadows, PhD, OMF's VP of Research Programs and Operations, on the clinical trial landscape in ME/CFS and Long COVID.

▶️ Watch at your own pace, and share with anyone who couldn't join live: https://ow.ly/WwBQ50ZSFYF

09/28/2026

Nearly 1,700 of you completed the Understanding Post-Exertional Symptom Worsening in ME/CFS survey.

These survey results go directly into CTN Lite trial design. They shape the outcome measures we select, the way we define and track PEM, and how we build trial protocols that can accommodate patients across the full severity spectrum.

👉 Dr. Danielle Meadows, OMF's VP of Research Programs, will walk through the results in a live webinar on October 7 at 3 PM ET.

She'll cover what you told us about post-exertional symptom worsening and crashes, what it means for CTN Lite trial design, and what comes next for the program.

Can't attend live? 🔗 Register anyway: https://ow.ly/uB6F50ZS0Qa

A recording goes out to everyone who signs up!

09/26/2026

Nearly 1,700 of you completed our deep dive survey on post-exertional symptom worsening, and we are so grateful to have your input on this critical topic.

In the survey we presented two frameworks: a staged model of post-exertional worsening, and a proposed set of outcome measures for decentralized treatment trials. Nearly 97% of respondents reported that our staged model covered or mostly covered their experience well. Almost 90% felt the proposed combination of tests would capture their experience very well or somewhat well.

These survey results go directly into CTN Lite trial design, and we continue to learn from patterns in your responses. They shape the outcome measures we select, the way we define and track PEM, and how we build trial protocols that can accommodate patients across the full severity spectrum.

Want to go deeper into the results? Join Dr. Danielle Meadows for a webinar on October 7 at 3 PM ET.

🔗 Learn more: https://ow.ly/xoyn50ZRSIA

09/23/2026

A Data Safety Monitoring Board (DSMB) is an independent group of medical and scientific experts who watch over a clinical trial while it's happening. They regularly review incoming data to make sure participants aren't being harmed and that the study is running fairly and ethically.

In ME/CFS clinical trials, a DSMB can be a critical safeguard for participants’ wellbeing, particularly in studies that are investigating drugs that haven’t been used frequently or at all in the disease. It can also add a layer of scientific credibility to trials, which is important for translating trial results into clinical practice.

OMF’s lite version of a clinical trial network (CTN Lite) will incorporate a DSMB for appropriate trials that are conducted as part of the initiative.

🔗 Read more about CTN Lite on our website: https://www.omfcanada.ngo/introducing-ctn-lite/

Address

2987 Baynes Road
Victoria, BC
V8N1Y4

Telephone

+14168480055

Website

http://www.omfcanada.ngo/

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