07/16/2026
Have you ever felt amazing after eating something sweet only to feel anxious, irritable or completely drained a few hours later?
This is your brain responding to rapid changes in your blood sugar.
When blood sugar rises quickly, your brain gets an immediate reward signal through dopamine. But if it crashes afterward, your body releases stress hormones like adrenaline to bring blood sugar back up—and those same hormones can make you feel anxious, restless or on edge.
Of course, anxiety and depression are incredibly complex conditions with many biological, psychological and social contributors. Blood sugar isn’t the whole story—but growing evidence suggests it’s one factor that’s often overlooked.
You don’t have to eliminate carbohydrates, but there are some strategies we can use to slow down the blood sugar spike they produce in our body.
Content credited to the excellent article by Dr. Mary Scourboutakos published in The Conversation. Thank you, Dr. Scourboutakos, for helping translate emerging nutrition science into practical information for the public.
Sources:
- Firth, J., et al. (2019). The effects of dietary improvement on symptoms of depression and anxiety: A meta-analysis of randomized controlled trials. Psychosomatic Medicine.
- Kwon, M., et al. (2023). Risk of depression and anxiety disorders according to long-term glycemic variability. Journal of Affective Disorders.
- Gangwisch, J. E., et al. (2015). High glycemic index diet as a risk factor for depression: Analyses from the Women’s Health Initiative. The American Journal of Clinical Nutrition.
- Ludwig, D. S.,et al. (1999). High glycemic index foods, overeating, and obesity. Pediatrics.
- Swami, V., et al. (2022). Hangry in the field: An experience sampling study on the impact of hunger on anger, irritability, and affect. PLOS ONE.
- Kopp, W. (2009). Chronically increased activity of the sympathetic nervous system: Our Diet-related “evolutionary” inheritance. The Journal of Nutrition, Health and Aging.
- Scourboutakos, M. (2024, August 20). Blood sugar fluctuations after eating play an important role in anxiety and depression. The Conversation.