08/29/2025
Thank you to everyone who shows up, organizes, donates, and fundraises for our HD Ride 4A Cure, with all funds raised going to Huntington’s disease research. Because of your dedication, scientists are exploring cutting edge life changing therapies:
Gene silencing, also called huntingtin‑lowering, works to reduce production of the toxic mutant huntingtin protein at the mRNA level using methods like antisense oligonucleotides (ASOs), RNA interference, or CRISPR-based tools. These are targeted, often reversible approaches that can ease the burden of the disease.  
Meanwhile, gene therapy introduces new genetic material into cells - typically via viral vectors - to block or slow the HTT gene’s harmful output. One example is AMT‑130, a one and done treatment using micro‑RNAs carried by a viral vector to dial down mutant huntingtin for potentially durable benefit. 
Because of your heart, this is the science moves forward. You’re fueling hope, not just for better treatments, but for brighter futures, for families, and for generations yet to come.
