Canadian Sepsis Foundation

06/02/2026

Background Sepsis affects an estimated 166 million people annually. Short-term survival has been the primary focus of research to date, yet individuals who surv...

05/28/2026

Australian researchers may have developed a therapeutic to impede sepsis from killing patients by preventing the cytokine storm that causes organ failure — survival rates jumped from 40% to 89%.

Sepsis — the body's catastrophic immune overreaction to infection — kills 11 million people annually, making it the leading cause of death in hospital intensive care units globally. The paradox of sepsis is that patients rarely die from the infection itself; they die from their own immune system's response, which triggers a cytokine storm that simultaneously causes uncontrolled clotting in small blood vessels, massive fluid leakage from capillaries, and multi-organ shutdown.

Researchers at the Walter and Eliza Hall Institute developed AntiSepsin — a monoclonal antibody targeting the HMGB1 protein, a late-stage inflammatory mediator released by dying immune cells that amplifies cytokine storm cascades. Unlike early-stage cytokine blockers that impair the patient's ability to fight infection, HMGB1 inhibition interrupts the damaging amplification loop that begins 16-32 hours into sepsis — after the initial immune response has addressed the infection but before the cascade destroys the organs.

In 180 ICU sepsis patients across Australian hospitals, AntiSepsin administered within the 16-32 hour window achieved 89% 28-day survival versus 40% in the control group receiving standard care alone. Organ failure scores improved in 94% of treated patients by day seven.

Source: Walter and Eliza Hall Institute & JAMA, 2024

05/24/2026

05/16/2026

Breaking: FDA Approves AI Sepsis Tool That Detects Infection Hours Earlier Than Doctors
Every hour that detection is delayed significantly reduces a patient's chance for survival
Sepsis Canada End Sepsis, The Legacy of Rory Staunton Sepsis Alliance

FRIDAY, May 15, 2026 (HealthDay News) — The U.S. Food and Drug Administration (FDA) has approved an AI-powered early warning system to detect sepsis, one o

05/14/2026

Infections post-partum are not new, yet there seems to be a lack of awareness related to symptom recognition and urgency.

Kimberley shares her story this week to raise awareness and save another family from .

In May 2024, my life changed in an instant. What was supposed to be a normal part of postpartum recovery turned into a nightmare when I developed an invasive Group A Strep infection that quickly became sepsis.

05/14/2026

The birth of a child is one of life’s most precious moments. Maternal Sepsis can affect any mother, turning what should be a joyful and life-changing experience into a medical emergency within hours. That’s why it’s important to spread awareness of Maternal Sepsis Week, to ensure we stay vigilant and do what we can to stop it from ruining such a magical moment.

For more information, follow this link:
https://www.endsepsis.org/what-is-sepsis/maternal-sepsis/

The birth of a child is one of life’s most precious moments. Maternal Sepsis can affect any mother, turning what should be a joyful and life-changing experience into a medical emergency within hours. That’s why we need to spread awareness of Maternal Sepsis Week, to ensure we stay vigilant and do what we can to stop it from ruining such a magical moment.

For more information, follow this link:
https://www.endsepsis.org/what-is-sepsis/maternal-sepsis/

04/23/2026

does not discriminate. has some real risks.

04/23/2026

Its Awareness week. It’s vital to remember that presents slightly differently in children compared to adults. Due to increased vagueness, it is crucial to seek medical help as soon as you suspect a child may have developed sepsis.

Signs of pediatric sepsis include:

• Cold and clammy hands and feet OR red and flushed skin
• Weak pulse
• Heart rate either much slower OR much quicker than normal
• Rapid breathing
• Confusion and decreased mental capabilities (relative to age and development)

Pediatric Sepsis Week is an opportunity to build awareness of these symptoms that may otherwise be overlooked.

It’s vital to remember that sepsis presents slightly differently in children compared to adults. Due to increased vagueness, it is crucial to seek medical help as soon as you suspect a child may have developed sepsis.

Signs of pediatric sepsis include:

• Cold and clammy hands and feet OR red and flushed skin
• Weak pulse
• Heart rate either much slower OR much quicker than normal
• Rapid breathing
• Confusion and decreased mental capabilities (relative to age and development)

Pediatric Sepsis Week is an opportunity to build awareness of these symptoms that may otherwise be overlooked.