09/06/2026
💉 GLP-1 receptor agonists - such as Wegovy, Ozempic and Mounjaro - are now widely used for weight loss, but past research suggests they come with a cost: muscle loss. Now, international researchers say taking the drug apitegromab could help preserve our lean body mass during weight loss with tirzepatide (Mounjaro), in a study funded by the producers of the drug. To work this out, the researchers gave 102 people with overweight or obesity either tirzepatide plus apitegromab or tirzepatide plus an inactive placebo for 24 weeks. The team says that, while the weight loss between the groups was similar, the people who received apitegromab lost 1.9 kg less lean mass than those who received the placebo, which would represent them holding on to 54.9% more lean muscle mass. Additionally, the researchers say the drug combination was well-tolerated and could be used in the future to help people retain their important muscle mass.
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