ISLUS

15/08/2023

One step forward for Ultrasound Imaging in liver diagnostics 🙌 “Certain ultrasound parameters have high diagnostic value in detecting liver steatosis and fibrosis, making way for attenuation imaging and shear-wave elastography, a study published July 26 in Academic Radiology found.”
https://www.auntminnie.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=140779

11/08/2023

Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus
https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-01945-x

11/08/2023

India is witnessing a worrying rise in the incidence of fatty liver disease, posing a potential risk of a surge in non-communicable diseases (NCDs) such as Diabetes and Heart ailments. https://weather.com/en-IN/india/health/news/2023-08-07-indias-illness-to-wellness-campaign-to-tackle-fatty-liver-disease

10/08/2023

In 2022, the World Health Organization reported that obesity and overweight, which are strong independent risk factors for MASLD, affect almost 60% of adults and nearly one in three children in Europe. With its increasing prevalence rate, MASLD is becoming the most common indication for liver transplantation and the main underlying aetiology for the development of liver cancer.

05/08/2023

[US] imaging, the standard method of surveillance for , has a sensitivity of only about 75%, falling to 50% in small cancers. In addition, it’s operator dependent. Alpha-fetoprotein [AFP] has been proposed as a marker for , but it is not enough as a stand-alone marker.

This study shows that a one-time evaluation of sound waves from the portal vein via Doppler US using AI can detect small HCCs with greater than 80% accuracy, and the combination of AFP and portal vein analysis can detect small HCCs with an accuracy of more than 95%

https://www.gastroendonews.com/Hepatology-in-Focus/Article/03-23/Novel-Use-of-Artificial-Intelligence-Shows-Promise-to-Improve-HCC-Detection/69656

04/08/2023

1,100 children enrolled in this study, 50-60% had MASLD (formerly known as NAFLD) and some as young as 8 years old. https://m-timesofindia-com.cdn.ampproject.org/v/s/m.timesofindia.com/city/hyderabad/watch-out-junk-food-hurting-your-kids-liver/amp_articleshow/102331199.cms?amp_js_v=0.1 =1&cap=swipe

01/08/2023

"We call it a silent epidemic because 90% of the people with fatty liver disease don't know they have had fatty liver disease. Unless they go through some tests, like an ultrasound or a blood test, they will have never known they had fatty liver disease," https://www-wbaltv-com.cdn.ampproject.org/v/s/www.wbaltv.com/amp/article/liver-disease-symptoms-womans-doctor/44692600?amp_js_v=0.1 =1&cap=swipe

24/07/2023

Lilly's Most Potent Weight Loss Drug Yet Could Help Manage Fatty Liver Disease, Too

-A new drug called retatrutide reduced body weight in study participants by up to 24%, according to mid-stage trial data shared by drugmaker Eli Lilly last month.

-In a small group study, Lilly also showed that retatrutide resolved liver fat in 9 out of 10 participants.

https://www.verywellhealth.com/lilly-retatrutide-obesity-medication-could-treat-liver-disease-7560270

23/07/2023

Alcohol Use Disorder and relationship to presented at :
“For patients with alcohol-related liver disease in earlier stages, we see a high progression rate — 15% progressed to decompensation,” Johansen said. “We also see high mortality rates, with 101 deaths within 6 years. Alcohol intake and fibrosis stage were the strongest predictors of events.”

https://www.healio.com/news/gastroenterology/20230623/nearly-15-of-patients-with-alcoholrelated-liver-disease-progress-to-decompensation

23/07/2023

4 Vitamins and Minerals for Liver Health: Vitamin E, Milk Thistle, Turmeric, and N-acetylcysteine

https://www.forbes.com/health/body/liver-detox-supplements/

28/06/2023

"…we need to get SAFE into primary care so these doctors can automatically calculate their scores, and if the patient is over 100 [high risk of chronic liver disease], then they need help [referral to a hepatologist]."

28/06/2023

Ray Kim, MD of Stanford University School Medicine, presents an algorithm, the Steatosis-Associated Fibrosis Estimator (SAFE), developed to detect clinically significant fibrosis in patients with nonalcoholic fatty liver disease (MASLD formarly known as NAFLD). It is effective at detecting chronic liver disease from all causes with or without [MASLD] in the general population, according the results of a US population-based study. The algorithm was designed for use in primary care to help slow the steep rise in liver disease burden. “Primary care doctors need to engage with the issue and have appropriate tools to identify people with liver disease."

The SAFE score can be used to detect chronic liver disease regardless of steatosis in the general population, offering the possibility for earlier detection in primary care.