05/05/2026
In the study, anxious dogs were given the medicinal mushroom Lion’s Mane (Hericium erinaceus) at a dose of 1000 mg per 10 kg of body weight (about 100 mg/kg) once daily for 28 days. This intervention led to a ~62% reduction in anxiety scores, with dogs improving to the point where they were no longer statistically different from healthy controls.
For families who cannot source Lion’s Mane, research suggests probiotics may offer a powerful alternative.
A 2025 peer-reviewed study published in the journal Animals (MDPI) found the probiotic strain Lactiplantibacillus plantarum LP815™ naturally produces GABA (gamma-aminobutyric acid), a neurotransmitter that helps calm the nervous system by regulating nerve activity. Unlike traditional calming supplements, LP815 works through the gut–brain axis to support more lasting, natural calming effects.
LP815 clinical results in dogs (after 4 weeks):
• Reduced fear- and noise-related aggression
• More restful, consistent sleep
• Improved mood and reduced reactivity
• Better energy and emotional balance
• Faster settling after owner departure
That’s why when developed her one-of-a-kind canine probiotic, she included Lactiplantibacillus plantarum LP815™ in PRIMITIVE PROBIOTICS™—a science-driven approach to rebuilding and maintaining your dog’s microbiome using strains inspired by wild canids, healthy domestic dogs, and living soil.
If you want to explore a science-backed probiotic option for your dog, comment BETTERBELLY and we’ll DM you the link.
