Conquer Aging Now Alliance

Conquer Aging Now Alliance Funding the future of longevity to conquer aging NOW. Donate at CanAll.org. .

04/28/2026

Life Biosciences has been named one of TIME’s 10 Most Influential New Frontiers Companies of 2026, along with IBM and SpaceX

This reflects years of work by a dedicated and focused team

From left to right: Dr. Michael Ringel (COO), Dr. Sharon Rosenzweig-Lipson (CSO), and Jerry McLaughlin (CEO). Not pictured: Amit Shashank (CAO), Ivan Kaplan (VP General Counsel) and my co-founder and founding CEO, Tristan Edwards

Grateful to the scientists, collaborators, and teams pushing this field forward

Early clinical efforts to treat vision loss with ER-100 are now underway

Cross your fingers for success 🤞

04/28/2026

🌱🔬 Study reveals that dandelion root can induce cancer cell su***de in over 90% of colon cancer cells within just 48 hours!

Dandelion root extract (DRE) appears to trigger apoptosis (programmed cell death) in aggressive cancer cells lines such colon cancer, melanoma and leukemia with minimal to no effect on healthy cells.

DRE targets the altered metabolic pathways within cancer cells. Research shows DRE disrupts the mitochondrial membrane potential and increases Reactive Oxygen Species (ROS) levels in cancer cells’ mitochondria.

Studies indicate that DRE can affect specific signaling pathways involved in cancer cell proliferation and survival. For instance, it may activate the extrinsic pathway of apoptoses, potentially involving caspase-8 activation.

In breast cancer, DRE may affect the P13K/AKT signaling pathways involved by inhibiting the expression of choline kinase α (CHKA).

DRE can also influence the expression of genes associated with cell death and survival. Studies show that DRE treatment led to the upregulation of pro-apoptotic genes and downregulation of anti-apoptotic genes in certain cancer cell lines.

PMID: 27564258

What are your thoughts on plant-based compounds in medical research? Have you come across any other interesting studies like this?

Disclaimer: This content is for informational and educational purposes only.

04/28/2026

What if aging could be slowed… by “turning off” inflammation at the metabolic level?

A groundbreaking study published in Nature Aging (March 2026) identifies a surprising player:
👉 A metabolic molecule called phosphoenolpyruvate (PEP)

Researchers found that PEP acts as an innate immune checkpoint, essentially putting “brakes” on chronic inflammation—also known as inflammaging.

Here’s what’s happening:
• PEP inhibits the cGAS–STING pathway (a major driver of inflammation)
• Helps reduce age-related immune overactivation
• Supports healthier aging and even cognitive function in models

The big idea:
👉 Aging isn’t just wear and tear—it’s also metabolic imbalance driving immune dysfunction

This opens new possibilities:
• Targeting metabolism to control inflammation
• Developing therapies for neurodegeneration
• Slowing aging at a cellular level

We’re now seeing metabolism, immunity, and aging converge into one system.

Read the research here:
https://www.nature.com/articles/s43587-026-01087-1⁠

04/28/2026

American biologists activated longevity genes that made old mice look and act completely young again. Scientists at the University of Pennsylvania showed that overexpressing SIRT6 — one of seven sirtuin proteins known to regulate aging — extended healthy lifespan in mice by thirty percent and reversed visible signs of aging, including fur graying, muscle loss, and cognitive decline. These animals didn't just live longer; they lived better, maintaining youthful vitality deep into old age.

Sirtuins are a family of NAD+-dependent deacylase enzymes that function as metabolic sensors and epigenetic regulators. SIRT6 specifically patrols the genome, repairing DNA double-strand breaks, silencing transposable elements (jumping genes that become active with age and destabilize the genome), and regulating glucose metabolism. When SIRT6 levels decline — as they naturally do with aging — DNA damage accumulates, inflammation rises, and metabolic efficiency plummets. The Penn team used a gene therapy approach to boost SIRT6 expression in middle-aged mice, essentially reinforcing the body's natural defense system before it collapsed.

The treated mice exhibited dramatically younger epigenetic profiles — their biological clocks literally wound backward. Telomere erosion slowed, senescent cell accumulation decreased, and stem cell reserves in bone marrow and intestine were replenished. Most remarkably, brain tissue showed reduced neuroinflammation and improved myelination, translating into sharper memory and faster reaction times on behavioral tests.

Pharmaceutical companies are now racing to develop small-molecule SIRT6 activators that can be taken orally. The challenge is specificity — you want to boost SIRT6 without disrupting the other six sirtuins, each of which has distinct roles. But the principle has been established: aging isn't just entropy. It's a loss of information that can be restored. The body's youth program never gets deleted — it just gets buried under decades of noise.

Source: University of Pennsylvania, Cell 2025

With BioViva Sciences Inc – We just made it onto their weekly engagement list by being one of their top engagers 🎉
04/28/2026

With BioViva Sciences Inc – We just made it onto their weekly engagement list by being one of their top engagers 🎉

04/28/2026

We are blessed to have great investors, allowing us to push the boundaries of human knowledge and medicine
🚀
The drug candidate ER-100, which was Invented by in my lab and optimized and tested in nonhuman primates by Dr. SharonSharon Rosenzweig-Lipson, has been allowed by FDA to be tested in patients to treat vision loss. is the first age reversal reprogramming technology to enter clinical trials
🤞
Cross your fingers for positive results because after the eye any organ or tissue is possible
🌎
Story .

04/28/2026

Biotech moves mitochondria into the clinic as longevity shifts from theory to human intervention.
ㅤ
Link in bio.
ㅤ

04/28/2026

Personalized mRNA vaccine shows rare long-term cancer survival

In a promising early-stage medical breakthrough, researchers have reported that a personalized mRNA vaccine designed for pancreatic cancer has shown encouraging long-term survival results in a Phase 1 clinical trial. Some patients involved in the study have reportedly survived beyond six years, which is especially significant for a disease known for its aggressive nature and low survival rates.

The vaccine works by training the immune system to recognize and attack cancer cells more effectively. Unlike traditional treatments such as chemotherapy, which target both healthy and cancerous cells, this approach is tailored to each patient’s unique tumor profile. Scientists analyze genetic markers from the tumor and design a customized mRNA instruction that helps the body identify cancer as a threat.

Pancreatic cancer is one of the most difficult cancers to treat due to its late detection and rapid progression. Standard treatments often provide limited survival benefits, making any improvement in long-term outcomes extremely important. This early trial suggests that personalized immunotherapy could potentially change how such cancers are approached in the future.

Experts emphasize that this is still an early Phase 1 trial, meaning the results are based on a small group of patients and require much larger studies to confirm effectiveness and safety. However, the survival outcomes have generated cautious optimism in the medical community.

If further research confirms these findings, personalized mRNA vaccines could mark a major shift in cancer treatment, turning some of the most deadly cancers into manageable conditions and offering renewed hope for patients worldwide.

04/22/2026

KTLA-TV reported on a clinical trial led by UCLA’s Dr. Donald Kohn that resulted in FDA approval of the first gene therapy for severe leukocyte adhesion deficiency-I, a rare and often fatal immune disorder. The treatment developed by Rocket Pharmaceuticals uses a patient’s own stem cells to rest...

Address

13 Sail Street
Jamestown, RI
02835

Telephone

+14018642607

Website

Alerts

Be the first to know and let us send you an email when Conquer Aging Now Alliance posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Organization

Send a message to Conquer Aging Now Alliance:

Shortcuts

Share

Category