12/08/2026
Is the chemical@imbalance theory a myth? 🤔
This week on Live Well Be Well, Sarah Ann is joined by Dr Mark Horowitz, clinical research fellow at University College London and North East London NHS Foundation Trust. He co-authored the Maudsley Deprescribing Guidelines, which have begun to change clinical guidance on antidepressant withdrawal worldwide, and has personally experienced withdrawal himself, which led him to dedicate his career to helping others through the same process.
Together they explore the science behind antidepressants, what they actually do to the brain, and what nobody told you about coming off them.
In this episode, you will learn:
😔 Why 1 in 6 people in England are on antidepressants, and whether we are overprescribing
🧠 What antidepressants actually do to the brain, and why the chemical imbalance theory is misleading
📈 Why 85% of people recover from depression within 12 months with no intervention at all
📉 What withdrawal actually feels like, and why doctors so often get it wrong
☝️What the alternatives to antidepressants are, and why they are rarely offered first
🎙️ Tune in now, wherever you get your podcasts